Our researchers want to find out if an investigational medication, a hyaluronic acid inhalation solution, can be used to treat alpha-1 antitrypsin deficiency (AATD) and emphysema. A common substance made by the human body, hyaluronic acid is found in the highest concentrations in the skin, joint fluid and eye.
In the lungs, hyaluronic acid is in the alveoli and the smallest airways. Hyaluronic acid has been used extensively in humans through injection to a specific area, such as the eyes, or to the body as a whole. Overall, patients have experienced few side effects. Giving patients hyaluronic acid through inhalation to the lungs has been done on a limited basis.