Impact of triple Combination Therapy for People with CF with Sinusitis

Trial Objective

Impact of triple Combination Therapy for People with CF with SinusitisThis observational study will assess the impact of a new triple combination CFTR modulator therapy on chronic sinusitis in adults with cystic fibrosis. This triple combination therapy is made up of the drugs, ivacaftor, tezacaftor and elexacaftor, and in previous studies has been shown to improve lung function and sweat chloride.

Researchers are trying to determine if this new triple combination therapy can also improve computed tomography sinus CT scan findings, sense of smell and quality of life for people with CF with chronic sinusitis.

Enrollment

This trial is active and currently recruiting.

Who Can Participate

Adults with chronic sinusitis and cystic fibrosis who are prescribed elexacaftor-tezacaftor-ivacaftor by their clinic doctor.

Age: 18-80    Gender: Any Gender


Estimated Time Commitment

6 months

This study will include a baseline visit lasting 2-3 hours at the beginning of the study and a follow up appointment lasting approximately 2 hours 6 months into the study. CT scans will be performed at both the baseline and follow-up visits. Participants are expected to receive monthly phone calls and take electronic surveys between the two appointments.



Compensation

Provided

Trial Contact

For more information, contact:

Connor Balkissoon

Connor Balkissoon
303.270.2768

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Trial Location

National Jewish Main Campus, Denver, CO

Trial Sponsors

Cystic Fibrosis Foundation and the Marshall and Margherite McComb Foundation

Principal Investigators


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