Genetic Modifiers of Alpha1-Antitrypsin Deficiency

Trial Objective

We are Looking for men and women that have been diagnosed with Alpha1-Antitrypsin Deficiency. National Jewish Health Health, in partnership with Brigham and Women''s Hospital, is conducting a research study to find out the genetic reasons why some people who have Alpha1-Antitrypsin Deficiency develop breathing problems while others do not.

To be eligible you must:

  • Be 30 years of age or older
  • Have a diagnosis of Alpha1-Antitrypsin deficiency
  • Have one or more siblings that are also diagnosed with Alpha1 -Antitrypsin deficiency or have unknown status

This research study involves 1 visit to the study clinic, which will last about 2-3 hours.  During this visit subjects will perform some breathing tests, complete a series of questionaires, and give a blood sample. Qualified participants will receive financial compensation for time and travel.


Active Clinical Trials Closed to Recruitment

How to Participate

For more information, contact a patient recruiter at 303.398.1911 or complete the form below.

Who Can Participate

Trial Location

Main Campus, Denver, CO



Principle Investigators

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    Robert Sandhaus, MD, PhD, FCCP