Efficacy and Safety of VX-814 in Alpha 1 PiZZ Genotype

Trial Objective

Efficacy and Safety of VX-814 in Alpha 1 PiZZ GenotypeThe purpose of this study is to learn more about the safety, tolerability and effectiveness of the investigational medication, VX-814, in people with Alpha-1 Antitrypsin Deficiency.


New enrollment for this trial is temporarily paused

Who Can Participate

People who have Alpha-1 Antitrypsin Deficiency may be eligible to participate in this study.

Age: 18-78    Gender: Any Gender

Estimated Time Commitment

42 days

If you are eligible and agree to be in the study, your participation will include a screening period, treatment period and follow-up period. The treatment period will last for 28 days and the follow-up period will last 14 days. In total, you may be asked to visit the study clinic about 8 times.

Payment & Reimbursement  

Payment: Provided

Travel Reimbursement: Available

Trial Contact

For more information, contact:

Kris Eliopoulos

Kris Eliopoulos

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Trial Location

National Jewish Main Campus, Denver, CO

Trial Sponsors

Vertex Pharmaceuticals Inc.

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Complete this form to learn more about this study and see if you qualify.