Dragone Laboratory

Lenny Dragone, MD, PhD

We are interested in developing strategies to manipulate lymphocyte-signaling pathways to treat autoimmune disease. We are defining how alterations in ubiquitinylation as well as NEDDylation alter signaling through the T-cell receptor complex in mouse models of inflammatory arthritis and systemic lupus erythematosus (SLE) to determine their role in autoimmune pathogenesis. 

In addition, we are defining the mechanism of pregnancy-induced arthritis amelioration as a means of identifying new signaling pathways that may be targeted to treat autoimmune disease.

Current Projects

  • The role of SLAP in the pathogenesis of SLE
  • The effects of SLAP-dependent ubiquitination of TCR on T-cell signaling
  • Defining the mechanism of arthritis remission in pregnancy
  • Understanding how alterations in TCR signaling influence the pathogenesis of RA

 

Figure 1

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 Collaborators

  • C. Jane McGlade, Toronto Hospital for Sick Children
  • Shimon Sakaguchi, Kyoto University
  • Michael Thomlinson, University of Birmingham
  • Dario Vignali, St Jude's Children's Research Hospital
  • Ji-Yang Wang, RIKEN Yokohama Institute
  • Virginia D. Winn, UCDSOM

Learn more.

Publications

  • Peterson, L., Wells, D., Shaw, L.A., Harbeck, R., Valez, M.G., and Dragone, L.L. Novel method for quantitative ANA measurement using near-infrared imaging. J Immunol Methods. 2009 Sep 30;349(1-2):1-8.
  • Dragone, L.L*, Shaw, L.A., Myers, M.D., and Weiss, A. SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking. Immunological Reviews. 2009; Nov 232: 218-228. (*Corresponding author)

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