Bowler Laboratory

Russell Bowler, M.D., Ph.D. obtained a B.S. in mathematical and computational sciences from Stanford University, a M.D. from the University of California at San Francisco (UCSF), and a Ph.D. in Cell and Developmental Biology from the University of Colorado (CU). He completed his internal medicine residency at UCSF and a pulmonary and critical care fellowship from CU.

The mission of our lab is to understand the mechanisms of how cigarette smoke leads to the development of chronic obstructive pulmonary disease (COPD). One of the major components of injury from cigarette smoke is oxidative stress (an imbalance between the bodies natural antioxidants and oxidizing agents induced by smoke). Our laboratory has published some of the key works implicating antioxidant enzymes such as extracellular superoxide dismutase as playing a role in the cigarette smoke response.

Lab Resources and Services

The Bowler Laboratory offers markers of oxidative stress, antioxidant measurement, 2-D gel electrophoresis, and translational research in COPD.

Current Projects

• Metabolome and proteome profiles of emphysema and airway disease
• Cigarette smoke induces endogenous oxidant injury
• Textural Approach to Quantification of Diffuse Lung Disease on CT