Research Interests
The Basic Science Section has a faculty whose diverse research interests in respiratory biology include:
Free Radical Biology Group
Russell Bowler, MD, PhD - Studies the use of genomics and proteomics in the development of oxidative stress biomarkers in lung disease
LingYi Chang, PhD - Drug development of catalytic antioxidants in bronchopulmonary dysplasia
Brian J. Day, PhD - Drug development of catalytic antioxidant porphyrins and the role of thiols in cellular redox regulated processes
Remy Kachadourian, PhD - Synthesis and redox cycling properties of metal complexes and the development of flavanoids as cancer agents
Elizabeth Regan, MD, PhD - Role of antioxidant defenses in joint disease
Cell Signaling Group
Rafuel Alam, MD, PhD - Signaling mechanism of activation of T cells and eosinophils, and the mechanism of airway inflammation in asthma
Hong Wei Chu, MD - TLR signaling in asthma, COPD, and bacterial infection
Greg Downey, MD - Role of tyrosine phosphatases in regulation of leukocyte activation
Magdalena Gorska, PhD - Studies how T cell receptor and cytokine receptors (e.g. IL-5R) activate Src tyrosine kinases
Hua Huang, MD PhD - Cytokine signaling pathways in the lung
William Janssen, MD - Role of stem cells and progenitor cells in response to lung injury and apoptotic cell clearance
Richard Martin, MD - Role of metalloproteinase cell signaling in asthma and COPD
Robert Mason, MD - Growth factor cell signaling pathways in cell injury and death
Jerry Nick, MD - Kinase cell signaling pathways in cystic fibrosis
Dennis Voelker, PhD - Lipid cell signaling pathways
Jieru Wang, MD, PhD - Interaction between type II cells and macrophages in the regulation of influenza-induced chemokine secretion
Acquired and Innate Immunity Group
Rafeul Alam, MD, PhD - Role of cytokines and signaling molecules in host defense
Hong Wei Chu, MD - Regulation of host defense (innate immunity) by allergic inflammation and cigarette smoke exposure
Brian J. Day, PhD - Role of glutathione and thiocyanate in lung host defense
Greg Downey, MD - Innate immune responses in lung epithelial cells
Hua Huang, MD, PhD - T helper cell and allergic effector cell differentiation in animal models of asthma
William Janssen, MD - Role of stem cells and progenitor cells in response to lung injury and apoptotic cell clearance
Lisa Maier, MD, MPH - Immunology of granulomatous lung diseases
Richard Martin, MD - The role of infection on modulating asthma and COPD
Robert Mason, MD - Viral infections and lung surfactant proteins
Jerry Nick, MD - Role of altered host defense in cystic fibrosis
Karin Pacheco, MD, MSPH - Interactions between innate immunity, acquired allergic responses, and occupational exposures
Jieru Wang, MD, PhD - Viral infections and type I and III interferons
Dennis Voelker, PhD - Role of phosphatidyl glycerol and surfactant proteins in lung infections
Environmental and Occupational Lung Group
Russell Bowler, MD, PhD - Role of oxidative stress associated with environmental tobacco smoke exposures
LingYi Chang, PhD - Morphological changes in the lung associated with ozone exposures
Brian J. Day, PhD - Role of oxidative stress in beryllium lung disease and thiol adaptive responses to environmental tobacco smoke
Roland du Bois, MD - Phenotyping of granulomatous lung diseases and occupational asthma
Greg Downey, MD - Role of environmental tobacco smoke in regulation of epithelial cell function
Beata Kosmider, PhD - Ozone-induced epithelial cell injury and apoptosis
Lisa Maier, MD, MSPH - Risk factors associated with sensitization and chronic beryllium disease, including beryllium exposure and gene by environment interactions
Richard Martin, MD - Effects of infection on the lung's response to environmental tobacco smoke
Robert Mason, MD - Ozone-induced epithelial cell injury and apoptosis
Karin Pacheco, MD, MSPH - Exposures and risk factors for occupational asthma and allergic diseases
Cecile Rose, MD, MSPH - Risk factors, mechanisms, and prevention of exposure-related granulomatous lung diseases, airway diseases, and pneumoconioses
David Schwartz, MD - The role of biological and genetic determinants in the onset of diseases that are influenced by environmental exposures
Respiratory Biodefense Group
Brian J. Day, PhD - Development of countermeasures against chemical warfare agent, sulfur mustard
Beata Kosmider, PhD - Role of apoptosis in viral infection
Robert Mason, MD - Virus-induced alveolar and epithelial cell injury and repair
Jieru Wang, MD, PhD - Influenza infection in human type II cells and alveolar macrophages
Genetics Group
Russell Bowler, MD, PhD - Genetic associations for COPD
Roland du Bois, MD - Genetic associations for pulmonary fibrosis, sarcoidosis, and granulomatous lung diseases
Lisa Maier, MD, MSPH - Genetic associations for granulomatous lung diseases, including sarcoidosis and chronic beryllium disease
Karin Pacheco, MD, MSPH - Genetic associations for occupational asthma and allergic disease
Cecile Rose, MD, MSPH - Genetic associations for hypersensitivity pneumonitis and pneumoconiosis
David Schwartz, MD - Investigates the role of biological and genetic determinants in the onset of diseases that are influenced by environmental exposures
