Publications

In the Center for Genes, Environment & Health (CGEH), we strive to publish our findings in top biomedical and basic science journals. Browse some of our selected publications and follow the links to read abstracts on PubMed.

Selected Pulmonary Fibrosis Publications

• Boon K, Bailey NW, Yang, J, Steele MP, Groshong S, Yang J, Kervitsky D, Brown KK, Schwarz MI, Schwartz DA. Molecular phenotypes distinguish patients with relatively stable from progressive Idiopathic Pulmonary Fibrosis (IPF). PLoS ONE 2009; 4:e5134. Abstract
• Garantziotis S, Zudaire E, Trempus CE, Hollingsworth JW, Jiang D, Lancaster LH, Richardson E, Zhuo L, Cuttitta F, Brown KK, Noble PW, Kimata K, Schwartz DA. Serum inter-alpha-trypsin inhibitor and matrix hyaluronon promote angiogenesis in fibrotic lung injury. Am J Resp Crit Care Med 2008; 178:939-947. Abstract
• Yang IV, Burch LH, Steele MP, Savov JD, Hollingsworth JW, McElvaniaTekippe E, Berman KG, Speer MC, Sporn TA, Brown KK, Schwarz MI, Schwartz DA. Gene Expression Profiling of Familial and Sporadic Cases of Interstitial Pneumonia. Am J Resp Crit Care Med 2007; 175:45-54. Abstract
• Steele MP, Speer MC, Loyd JE, Brown KK, Herron A, Slifer SH, Burch LH, Phillips JA, Sporn TA, McAdams HP, Schwarz MI, Schwartz DA. Clinical and pathologic features of familial interstitial pneumonia (FIP). Am J Resp Crit Care Med 2005; 172:1146-1152. Abstract

Selected Innate Immunity Publications

• Yang IV, Wade CM, Kang HM, Alper S, Rutledge H, Lackford B, Eskin E, Daly MJ, Schwartz DA. Identification of novel genes that mediate innate immunity using inbred mice. Genetics. 2009; 183:1535-44. Abstract
• Zaas AK, Liao G, Chien J, Weinberg C, Shore D, Giles SS, Marr KA, Usuka J, Burch L, Perara L, Perfect JR, Schwartz DA. Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis. PLOS Genetics 2008; 4:e1000101. Abstract
• Alper S, Laws R, Lackford B, Boyd WA, Dunlap P, Freedman JH, Schwartz DA. Identification of innate immunity genes and pathways using a comparative genomics approach. Proc Nat Acad Sciences 2008; 105:7016-7021. Abstract
• Hollingsworth JW, Maruoka S, Li Z, Potts EN, Foster WM, Schwartz DA. Ambient ozone primes pulmonary innate immunity in mice. J Immunology 2007; 179:4367-4375. Abstract
• Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol 2004; 5:975-979. Abstract
• Cook, DN, Wang S, Wang Y, Howles GP, Whitehead GS, Berman K, Church TD, Frank B, Gaspard R, Yu Y, Quackenbush J, Schwartz DA. Genetic regulation of endotoxin-induced airway disease. Genomics 2004; 83:961-969. Abstract
• Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis in humans. N Engl J Med 2002; 347:185-192. Abstract
• Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutation is associated with endotoxin hyporesponsiveness in humans. Nature Genetics 2000; 25:187-191. Abstract

Selected Asthma Epigenetics Publications

• Boon K, Tomfohr JK, Bailey NW, Garantziotis S, Li Z, Brass DM, Maruoka S, Hollingsworth JW, Schwartz DA. Evaluating genome-wide DNA methylation changes in mice by Methylation Specific Digital Karyotyping. BMC Genomics 2008; 9:598. Abstract
• Hollingsworth JW, Maruoka S, Boon K, Brass DM, Tomfohr J, Garantziotis S, Li Z, Bailey N, Potts E, Schwartz DA. In utero supplementation with methyl-donors enhances allergic airway disease in mice. J Clin Invest 2008; 118:3462-3469. Abstract

Selected Infectious Disease Publications

• Sandgren A, Strong M, Mutukrishnan P, Weiner BK, Church GM, Murray MB. Tuberculosis Drug Resistance Mutation Database. PLoS Medicine 2009; 6:2. Abstract
• Strong M, Eisenberg D. The Protein Network as a Tool for Finding Novel Drug Targets.  Progress in Drug Research 2007; 64:193-215. Abstract
• Strong M, Sawaya M, Wang S, Philips M, Cascio D, Eisenberg D. Toward the Structural Genomics of Complexes: Crystal Structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 2006; 103:8060-8065. Abstract
• Strong M, Goulding C. Structural Proteomics and Computational Analysis of a Deadly Pathogen: Combating M. tuberculosis from Multiple Fronts. Methods Biochem Analysis 2006; 49:245-69. Abstract
• Rachman H, Strong M, Ulrichs T, Grode L, Schuchhardt J, Mollenkopf H, Kosmiadi GA, Eisenberg D, Kaufmann SHE. Unique Transcriptome Signature of Mycobacterium tuberculosis in Pulmonary Tuberculosis.  Infection and Immunity 2006; 74:1233-1242. Abstract
• Rachman H, Strong M, Schaible U, Schuchhardt J, Hagens K, Mollenkopf H, Eisenberg D, Kaufmann SH. Mycobacterium tuberculosis Gene Expression Profiling within the Context of Protein Networks.
  Microbes and Infection 2006; 8:747-757. Abstract
• Strong M, Graeber TG, Beeby M, Pellegrini M, Thompson MJ, Yeates TO, Eisenberg D. Visualization and Interpretation of Protein Networks in Mycobacterium tuberculosis Based on Hierarchical Clustering of Genome-Wide Functional Linkage Maps. Nucleic Acids Research 2003; 31: 7099-7109. Abstract
• Strong M, Mallick P, Pellegrini M, Thompson MJ, Eisenberg D. Inference of Protein Function and Protein Linkages in M. tuberculosis Based on Prokaryotic Genome Organization: A Combined Computational Approach. Genome Biology 2003; 4:R59.1-R59.16. Abstract