The Center for Genes, Environment & Health (CGEH) is an interdisciplinary program dedicated to understanding the genetics of complex lung and immune-related conditions. The Center builds on the scientific and clinical strengths at National Jewish Health by developing programs to understand how genes work in biological systems, how genetic variants contribute to the development of disease, and why individuals with the same disease have very different results due to the treatment. These approaches will enable clinicians to develop innovative approaches to disease prevention, early diagnosis and personalized therapeutic intervention.