Huang Lab: Publications

Gao FM, Li XL, Huang H, Wang WH. [In vitro studies of the cell cycle of mouse myelomonocytic leukemia using a fluorescence activated cell sorter and autoradiography]. Zhonghua Zhong Liu Za Zhi. 1987 Jan; 9(1): 10-3. Chinese.

Huang H, Meyer KC, Kubai L, Auerbach R. An immune model of beryllium-induced pulmonary granulomata in mice. Histopathology, immune reactivity, and flow-cytometric analysis of bronchoalveolar lavage-derived cells. Lab Invest. 1992 Jul; 67(1): 138-46.

Kusunoki Y, Huang H, Fukuda Y, Ozaki K, Saito M, Hirai Y, Akiyama M. A positive correlation between the precursor frequency of cytotoxic lymphocytes to autologous Epstein-Barr virus-transformed B cells and antibody titer level against Epstein-Barr virus-associated nuclear antigen in healthy seropositive individuals. Microbiol Immunol. 1993; 37(6): 461-9.

Kusunoki Y, Kyoizumi S, Fukuda Y, Huang H, Saito M, Ozaki K, Hirai Y, Akiyama M. Immune responses to Epstein-Barr virus in atomic bomb survivors: study of precursor frequency of cytotoxic lymphocytes and titer levels of anti-Epstein-Barr virus-related antibodies. Radiat Res. 1994 Apr; 138(1): 127-32.

Huang H, Auerbach R. Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo. Proc Natl Acad Sci U S A. 1993 Nov 1;90 (21): 10110-4.

Huang H, Zettergren LD, Auerbach R. In vitro differentiation of B cells and myeloid cells from the early mouse embryo and its extra embryonic yolk sac. Exp Hematol. 1994 Jan; 22(1): 19-25.

Auerbach R, Huang H, Lu L. Hematopoietic stem cells in the mouse embryonic yolk sac. Stem Cells. 1996 May; 14 (3): 269-80.

Huang H, Hu-Li J, Chen H, Ben-Sasson SZ, Paul WE. IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent. J Immunol. 1997 Oct 15; 159(8): 3731-8.

Ryan JJ, Huang H, McReynolds LJ, Shelburne C, Hu-Li J, Huff TF, Paul WE. Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cells. Exp Hematol. 1997 Apr; 25(4): 357-62.

Chen H, Huang H, Paul WE. NK1.1+ CD4+ T cells lose NK1.1 expression upon invitro activation. J Immunol. 1997 Jun 1; 158(11): 5112-9.

Hu-Li J, Huang H, Ryan J, Paul WE. In differentiated CD4+ T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent. Proc Natl Acad Sci USA. 1997 Apr 1; 94(7): 3189-94.

Huang H, Paul WE. Impaired interleukin 4 signaling in T helper type 1 cells. J Exp Med. 1998 Apr 20; 187(8): 1305-13.

Ryan JJ, McReynolds LJ, Huang H, Nelms K, Paul WE. Characterization of a mobile Stat6 activation motif in the human IL-4 receptor. J Immunol. 1998 Aug 15; 161(4): 1811-21.

Huang H, Pannetier C, Hu-Li J, Paul WE. Transient transfection of primary T helper cells by particle-mediated gene transfer. J Immunol Methods. 1998 Jun 1; 215 (1-2): 173-7.

Nelms K, Huang H, Ryan J, Keegan A, Paul WE. Interleukin-4 receptor signaling mechanisms and their biological significance. Adv Exp Med Biol. 1998; 452:37-43.

Huang H, Paul WE. Protein tyrosine phosphatase activity is required for IL-4 induction of IL-4 receptor alpha-chain. J Immunol. 2000 Feb 1; 164(3):1211-5.

Zhu J, Huang H, Guo L, Stonehouse T, Watson CJ, Hu-Li J, Paul WE. Transient inhibition of interleukin 4 signaling by T cell receptor ligation. J Exp Med. 2000 Oct 16; 192(8): 1125-34. (co-first author).

Zhang Y, Apilado R, Coleman J, Ben-Sasson S, Tsang S, Hu-Li J, Paul WE, Huang H. Interferon gamma stabilizes the T helper cell type 1 phenotype. J Exp Med. 2001 Jul 16; 194(2): 165-72.

Chen L, Grabowski KA, Xin JP, Coleman J, Huang Z, Espiritu B, Alkan S, Xie HB, Zhu Y, White FA, Clancy J Jr, Huang H. IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophil’s. J Immunol. 2004 Feb 15; 172(4): 2059-66.

Zhu Y, Chen L, Huang Z, Alkan S, Bunting KD, Wen R, Wang D, Huang H. Cutting edge: IL-5 primes Th2 cytokine-producing capacity in eosinophil’s through a STAT5-dependent mechanism. J Immunol. 2004 Sep 1; 173(5):2918-22.

Huang Z, Coleman JM, Su Y, Mann M, Ryan J, Shultz LD, Huang H. SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner. Cytokine. 2005 Feb 7; 29(3):118-24.

Huang Z, Xin J, Coleman J, Huang H. IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor. J Immunol. 2005 Feb 1; 174 (3):1332-7.

Wu, C. Y., Yang B. Y., Zhu, Z. L., and Huang, H. Analysis of linkage of antigen-specific Th1/Th2 cytokines at a single cell level.  Chinese Journal of Immunology. 2: 9-12 (2005). (This is a collaborative work as result of being a visiting professor in Sun Yat-sen University Medical School, which is my alma mater).

Xin J, Ohmori K, Nishida J, Zhu Y, Huang H. The initial response of CD4+ IL-4-producing cells. Int Immunol. 2007 Mar; 19(3):305-10. Epub 2007 Jan 30.

Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H. IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. JImmunol. 2009 Mar 1; 182(5):2835-41.

Zhuang Y, Huang Z, Nishida J, Brown M, Zhang L, Huang H. A continuous T-bet expression is required to silence the interleukin-4-producing potential in T helper type 1 cells. Immunology. 2009 Sep; 128(1):34-42.

Zhuang Y, Huang Z, Nishida J, Zhang L, Huang H. Signaling pathways that lead to the silencing of the interleukin-4-producing potential in Th1 cells. J Interferon Cytokine Res. 2009 Jul; 29(7):399-406.                                 

Huang Y, Jin N, Roark CL, Aydintug MK, Wands JM, Huang H, O'Brien RL, Born WK. The influence of IgE-enhancing and IgE-suppressive gamma delta T cells changes with exposure to inhaled ovalbumin. J Immunol. 2009 Jul 15;183(2):849-55. Epub 2009 Jun 19.

Bai X, Kim SH, Azam T, McGibney MT, Huang H, Dinarello CA, Chan ED. IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol. 2010 Apr 1; 184(7):3830-40. Epub 2010 Feb 26.

Born WK, Huang Y, Jin N, Huang H, O'Brien RL. Balanced approach of gamma delta T cells to type 2 immunity. Immunol Cell Biol. 2010 Mar-Apr; 88(3):269-74. Epub 2010 Jan 26.

Ma D, Huang H, Huang Z. STAT1 signaling is required for optimal Th1 cell differentiation in mice. Chinese Science Bulletin. April 2010, Volume 55, Issue 11, pp1032-1040.

Qi X, Nishida J, Chaves L, Ohmori K, Huang H. CCAAT/enhancer-binding     protein alpha (C/EBPalpha) is critical for interleukin-4 expression in response to FcepsilonRI receptor cross-linking. J Biol Chem. 2011 May 6; 286(18):16063-73. Epub 2011 Mar 21.

Huang H. Suppressing allergic immune responses. Front Biosci (Elite Ed). 2011 Jun 1; 3:864-70

Hua Huang and Xiopeng Qi. Differentiation of Innate Type-2 Effector Cells. Immunologic Research, 2012. Online: DOI: 10.1007/s12026-012-8361-z; Print: 55:173-177, 2013.

Roza I. Nurieva, Andrew Podd, Yuhong Chen, Andrei M. Alekseev, Mei Yu, Xiaopeng Qi, Hua Huang, Renren Wen, Junmei Wang, Haiyan S. Li, Stephanie S. Watowich, Chen Dong, Demin Wang. STAT5 Negatively Regulates Follicular Helper T cell Generation and Function.  J. Biol. Chem. 2012 Feb 8 doi:10.1074/jbc.M111.324046

Nicholas Goplen, Md. Zunayet Karim, Lei Guo, Yonghua Zhuang, Hua Huang, Magdalena M. Gorska, Erwin Gelfand, Gilles Pagés, Jacques Pouysségur, and Rafeul Alam.  ERK1 is Important for Th2 Differentiation and Development of Experimental Asthma.  FASEB J 2012 Jan 18, doi:10.1096/fj.11-196477.

Jyoti Thaikoottathil, Richard J. Martin, Peter Y. Di, Maisha Minor, Stephanie Case, Fangkun Ning, Sean Smith, Bicheng Zhang, Gyogi Zhang, Hua Huang, Hong Wei Chu.  SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice.  Am J Respir Cell Mol Biol.  2012 doi:/10.1165/rcmb.2012-0064OC.

Hua Huang, Yapeng Li and Xiopeng Qi.  Cytokine Signaling in the Differentiation of Innate Effector Cells. Jak-Stat, 2013, 2:105-111, 2013.

Henry Milgrom and Hua Huang.  Allergic Disorders at a Venerable Age, Gerontology, in press, 2013.

Jun Nishida, Yapeng Li, Younghua Zhuang, Zan Huang, and Hua Huang. IFN- suppresses permissive chromatin remodeling in the regulatory region of the Il4 gene.  Cytokine, 62: 91–95, 2013.

Xiaopeng Qi, Lee Chaves, Yonghua Zhuang, Yuhong Chen, Demin Wang, Jacob Chahon, Brian Graham, Keitaro Ohmori, and Hua Huang.  Antagonistic regulation by transcription factors C/EBPa and MITF specifies basophil and mast cell fates.  Immunity, 39, 97-110; 10.1016/j.immuni.2013.06.012, published online, July 18, 2013

Zhihong Chen, Shanze Wang, Nkiruka Erekosima, Jessie Hong, Xiaopeng Qi, Yapeng Li, Patricia Merkel, Vijaya Nagabhushanam, Eugene Choo, Rohit Katial, Rafeul Alam, Hong Wei Chu, Yonghua Zhuang, Meiling Jin, Chunxue Bai, and Hua Huang. IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing STAT1 signaling. J Allergy Clin Immunol, in press, 2013.

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