Day Lab: Current Projects and Grant Support

 

NIH RO1 ES017582-01

Targeting Oxidative Stress in Chronic Beryllium Disease

P.I. Brian J. Day

Total Award Period: 7/01/09 – 6/30/14

Goals: To (1) examine the effect of beryllium on APC antioxidant status and oxidative response; (2) examine the effect of altered antioxidant status on antigen presentation by APC and T cell activation responses to beryllium; (3) examine the role of oxidative stress on antigen presentation by APC and T cell activation responses to beryllium.

 


NIH RO1 HL084469

Adaptive glutathione responses to cigarette smoke in COPD

P.I. Brian J. Day

Total Award Period: 12/1/07 – 11/31/11

Goals: The overall goal of this application is to determine the role of glutathione (GSH) adaptive responses to cigarette smoke which is a major risk factor in chronic obstructive pulmonary disease (COPD). The specific aims are to: 1) examine mechanism(s) responsible for GSH adaptive responses stimulated by cigarette smoke; 2) examine whether defective extracellular GSH adaptive responses contributes to enhanced cigarette smoke-induced lung epithelial cell oxidation and injury upon exposure to extracellular oxidants; 3) Examine whether defective GSH transport sensitizes the lung to cigarette smoke-induced oxidative stress and inflammation.

 


NIH U54 ES015678-01 (CounterACT)

Novel Antioxidant Therapeutics for Sulfur Mustard Toxicity

Director Carl White

Project 2 Leader Brian J. Day

Total Award Period: 9/15/06 – 9/14/11

The overall goals of this project are to develop an effective treatment for mustard gas-induced injury. The specific aims are to: 1) determine the efficacy of catalytic antioxidants in rat and human models of CEES-induced lung injury; 2) determine the efficacy of catalytic antioxidants in mouse and human models of CEES-induced dermal injury; 3) develop and characterize a new class of catalytic antioxidants, the linear tetrapyrroles.

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Events

MAY
01
New York AIR Society
5/1/2014 7:00:00 PM
MAY
17
Cocktails with Class
5/17/2014 6:00:00 PM