Gerber Laboratory

Anthony N Gerber, MD, PhD The Gerber lab seeks to bridge the gap between the basic science of glucocorticoid receptor (GR) biology, and clinical therapeutics in pulmonary disease. To accomplish this, we are investigating two basic aspects of glucocorticoid action in the lung. In one area of study, we are investigating the lung-specific function of two members of the Kruppel-like family of transcription factors that are regulated by glucocorticoids, Klf9 and Klf15. In another approach, we are decoding the primary and secondary transcriptional responses to glucocorticoids in airway cells. Through developing a greater understanding of these two aspects of GR function, we seek to identify novel candidates for therapeutic targeting to treat lung disease.

 

Lab Resources and Services

The Gerber laboratory is located on the 6th floor of the Goodman building on National Jewish Health’s campus. Learn more.

 

Current Projects

    Personnel

    Collaborators

    Jae Yeon Choi, PhD
    Pitchaimani Kandasamy, PhD
    Wayne Riekhof, PhD
    Masami Yamazoe, MD, PhD
    Sasipa Tanyaratsrisakul, PhD
    Geetha Ramakrishnan, PhD

    Publications

    Masuno K., Haldar S.M., Jeyaraj D., Mailloux C.M., Huang X., Panettieri R.A., Jain M.K., Gerber A.N.  2011. Expression Profiling Identifies Klf15 as a Glucocorticoid Target that Regulates Airway Hyperresponsiveness.  Am J Respir Cell Mol Biol. 2011 Jan 21 [Epub ahead of print]. Abstract

    Gerber, A.N., Masuno K., and Diamond M.I.  Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4929-34. Abstract


    More Publications

    Basic Science Section

    The BSS is an interdivisional program in the Department of Medicine that facilitates and promotes basic science discovery at National Jewish Health. Learn more.

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