Recent Publications

Marrack, P., Scott-Browne, J.P., Dai, S., Gapin, L. and Kappler, J. Evolutionarily conserved amino acids in TCR V regions and MHC control their interaction. Annual Reviews of Immunology, 26:203-207, 2008. PMC3164820.

Clambey, E.T., White, J., Kappler, J.W. and Marrack, P. Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties. Proc. Natl. Acad. Sci. USA 105:12997–13002, 2008. PMC2525558

Scott-Browne, J.P., White, J., Kappler, J.W., Gapin, L. and Marrack, P. Germline-encoded amino acids in the aß T cell receptor control thymic selection. Nature 458:1043-1046, 2009. PMC2679808

Desbien, A., Kappler, J. and Marrack, P. The Epstein Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim. PNAS, 106:5663-5668, 2009. PMC 2657086.

McKee, A.S., Munks, M.W., MacLeod, M.K., Fleenor, C.J., van Rooijen, N., Kappler, J.W. and Marrack, P. Alum induces innate immune responses through macrophage and mast cell sensors, but these are not required for alum to act as an adjuvant for specific immunity. J. Immunol. 183: 4403-4414, 2009. PMC2912728.

Stadinski, B., Delong, T., Reisdorph, N., Reisdorph, R., Powell, R., Armstrong, M., Piganelli, J., Barbour, G., Bradley, B., Marrrack, P., Mahata, S.K., Kappler, J. and Haskins, K. Chromogranin A is a Major T Cell Autoantigen in Type 1 Diabetes. Nat. Immunol. 11: 225-231, 2010. PMC 3166626.

McKee, A.S., MacLeod, M.K.L., Kappler, J.W. and Marrack, P. Immune mechanisms of protection: can adjuvants rise to the challenge? J. Biol. 8:37, 2010. PMC2864095.

Stadinski, B.D., Zhang, L., Crawford, F., Marrack, P., Eisenbarth, G.S. and Kappler, J. W., Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc. Natl. Acad. Sci. USA 107: 10978-10983, 2010. PMC 2890771.

Munks, M.W., McKee, A.S., MacLeod, M.K.., Powell, R., Brinkmann, V., Zychlisky, A., Degen, J.L., Reisdorph, N.A., Kappler, J.W. and Marrack, P. Aluminum Adjuvants Elicit Fibrin-Dependent Extracellular Traps in vivo. Blood 116:5191-5199, 2010. PMC 3012537.

MacLeod, M.K.L., McKee, A.S., David, A., Wang, J., Mason, R.J., Kappler, J.W. and Marrack, P. Vaccine adjuvants Aluminum and Monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc. Natl. Acad. Sci. USA 108:7914-7919, 2011. PMC 3093483.

Rubtsov, A.V., Rubtsova, K., Fischer, A., Meehan, R.T., Gillis, J.,Z., Kappler, J.W. and Marrack, P. Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B cell population is important for the development of autoimmunity. Blood 118:1305-1315, 2011. PMC in process.

Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S and Kappler J.W. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers. Immunity. 35:23-33, 2011. PMC in process.

Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, Kappler JW. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A. 108:16729-34, 2011. PMC3189014.

Scott-Browne, J. P., Crawford, F., Young, M.H., Kappler, J.W., Marrack, P*. and Gapin, L.* Evolutionarily conserved features of the aß T cell receptor contribute to its MHC specificity. Immunity 35:526-535, 2011. PMC in process. * These authors contributed equally to the work.

Marrack, P. and Kappler, JW. Do MHCII presented neo-antigens drive type-1 diabetes and other autoimmune diseases? Cold Spring Harbor Prospectives in Medicine. Diabetes CSH Laboratory Press Bluestone J., Editor. In press 2012. PMC in process.