Leach Laboratory

Sonia LeachWe are interested in the development of computational tools to facilitate data interpretation and scientific discovery for biologists and clinicians. Researchers now have access to multiple types of genomic-scale data but are left with the daunting challenge of interpreting within and between data sets. This challenge is one shared globally as a number of large-scale projects have been funded to create comprehensive molecular characterizations of processes or diseases of interest, but the data remains largely unexplored for lack of effective analysis approaches. The pervading theme in our work is the integration of heterogeneous data sources, commonly referred to as data fusion, with applications to characterizing genes and their inter-relationships.

Our work also emphasizes graphical network representations of gene interactions and the use of those networks for interpreting and focusing hypothesis generation and validation of datasets contributed by our collaborators. We are especially interested in applications which truly invoke the systems biology mandate of feedback and iteration between data generation and modelling, thereby encouraging strong interplay between researchers with biological/clinical backgrounds and those with a computational background.
 

Lab Resources and Services

We have access to the resources of the Integrated Center for Genes, Environment and Health, including a high performance computer cluster, Applied Biosystems SOLiD and 454 next-generation sequencers, an Applied Biosystems 96-capillary 3730XL DNA analyzer, Nimblegen and Agilent microarray scanners, an Illumina's BeadXpress for Multiplex SNP Genotyping, and Qiagen BioRobots for liquid handling. Learn more.


Current Projects

 

Contact Information

Sonia Leach, PhD
National Jewish Health
Integrated Center for Genes, Environment and Health
Smith Building, Room A656
1400 Jackson Street
Denver, CO 80206
Office Phone: 303.270.2568
email: LeachS@NJHealth.org

Collaborators

 

Publications

Yu S, Tranchevent L, Leach SM, De Moor B, Moreau Y. A kernel based framework for cross-species candidate gene prioritization, Machine Learning in Systems Biology, 2011

Leach SM, Tipney H, Feng W, Baumgartner WA, Kasliwal P, Schuyler RP, Williams T, Spritz RA, Hunter L. Biomedical Discovery Acceleration, with Applications to Craniofacial Development. PLoS Comput Bio, 2009, 5(3):e1000215. Abstract

More publications

 

Lung Genomics Research Consortium

This multi-center Consortium uses advanced genetic and molecular tools to characterize and better understand COPD and pulmonary fibrosis.
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Familial Pulmonary Fibrosis Research

National Jewish Health has teamed with Duke University and Vanderbilt University to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis.
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NTM Center for Excellence

The Nontuberculous Mycobacteria (NTM) Center of Excellence is comprised of National Jewish Health physicians and researchers dedicated to enhancing the clinical care for all patients with NTM infections, and expanding the body of knowledge on NTM through translational research.

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Integrated Center for Genes, Environment & Health

This is an interdisciplinary program dedicated to understanding the genetics of complex lung and immune-related conditions common in patients cared for at National Jewish Health. Learn more.