Seibold Lab

Max SeiboldThe Seibold Lab is focused on identifying genetic determinants and biomarkers of complex lung diseases, including asthma and pulmonary fibrosis. Many of the genetic variants that influence development and severity of these lung diseases do so by altering molecular functions in specific lung cell types. His lab is focused on identifying dysregulated molecular functions in patient lung cells, by Nex-Generation sequencing technologies. Using patient cohorts the genetic determinants of these molecular changes are then mapped. The lab is also editing the genome of these lung cells to allow detailed mechanistic studies of disease variants and better understanding of how these genetic changes increase risk of disease development.

The Seibold Lab is currently seeking students and post-doctoral fellows to be part of a collaborative team working to identify genetic determinants of complex lung diseases through the use of genetic epidemiology and molecular genetics.

Learn about open positions in this lab.

 

Current Projects

  1. Nasal Airway Epithelia Expression Genetics and Epigenetics in Puerto Rican Asthmatics.
  2. Functional characterization of an IPF genetic risk variant.
  3. Genomic editing of primary lung cells.
  4. Genetics of expression in asthmatic bronchial epithelium

 

Personnel

 

Contact Information

Dr. Max A. Seibold
SeiboldM@NJHealth.org
Office: 303.270.2544
Lab: 303.270.2650

Shereen Khwajazada
KhwajazadaS@NJHealth.org
Office: 303.270.2769

 

Publications

A common MUC5B promoter polymorphism and pulmonary fibrosis. Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, Evans CM, Garantziotis S, Adler KB, Dickey BF, du Bois RM, Yang IV, Herron A, Kervitsky D, Talbert JL, Markin C, Park J, Crews AL, Slifer SH, Auerbach S, Roy MG, Lin J, Hennessy CE, Schwarz MI, Schwartz DA.

N Engl J Med. 2011 Apr 21;364(16):1503-12.

More Publications

Lung Genomics Research Consortium

This multi-center Consortium uses advanced genetic and molecular tools to characterize and better understand COPD and pulmonary fibrosis.
Learn more.

 

Familial Pulmonary Fibrosis Research

National Jewish Health has teamed with Duke University and Vanderbilt University to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis.
Learn more.

 

NTM Center for Excellence

The Nontuberculous Mycobacteria (NTM) Center of Excellence is comprised of National Jewish Health physicians and researchers dedicated to enhancing the clinical care for all patients with NTM infections, and expanding the body of knowledge on NTM through translational research.

Learn more.

Integrated Center for Genes, Environment & Health

This is an interdisciplinary program dedicated to understanding the genetics of complex lung and immune-related conditions common in patients cared for at National Jewish Health. Learn more.