Alper Laboratory

Scott Alper, PhDDiseases of the immune system such as sepsis, asthma, and atherosclerosis affect millions of people worldwide, and the incidence of many of these diseases is rising. Dr. Alper's lab is focused on understanding the regulation of the innate immune response, particularly as it relates to the basis for such immunological diseases. He is using a comparative genomics approach in the nematode C. elegans and mammalian cell culture to identify novel regulators of the innate immune response, and is testing the effect of these regulators in mammalian disease models.

The Alper lab is supported by grants from the American Lung Association and the National Institute of Environmental Health Sciences.

Learn about open positions in this lab.


Current Projects




Contact Information

Dr. Scott Alper
Office: 303.270.2659
Lab: 303.270.2698

Access Dr. Alper's University of Colorado Denver page.



  • De Arras, L, Laws, R, Leach, S, Pontis, K, Freedman, JH, Schwartz, DA and Alper, S. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. Genetics published online Dec 20 (2013).
  • De Arras, L and Alper, S. Using RNAi-interference to investigate the innate immune response in mouse macrophages. J. Vis. Exp. in press (2013).

More Publications

Lung Genomics Research Consortium

This multi-center Consortium uses advanced genetic and molecular tools to characterize and better understand COPD and pulmonary fibrosis.
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Familial Pulmonary Fibrosis Research

National Jewish Health has teamed with Duke University and Vanderbilt University to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis.
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NTM Center for Excellence

The Nontuberculous Mycobacteria (NTM) Center of Excellence is comprised of National Jewish Health physicians and researchers dedicated to enhancing the clinical care for all patients with NTM infections, and expanding the body of knowledge on NTM through translational research.

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