Diseases of the immune system such as sepsis, asthma, and atherosclerosis affect millions of people worldwide, and the incidence of many of these diseases is rising. Dr. Alper's lab is focused on understanding the regulation of the innate immune response, particularly as it relates to the basis for such immunological diseases. He is using a comparative genomics approach in the nematode C. elegans and mammalian cell culture to identify novel regulators of the innate immune response, and is testing the effect of these regulators in mammalian disease models.
The Alper lab is supported by grants from the American Lung Association and the National Institute of Environmental Health Sciences.
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Dr. Scott Alper
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- De Arras, L. Yang, IV, Lackford, B, Riches, DWH, Prekeris, R, Freedman, JH, Schwartz, DA, and Alper, S. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J. Immunol. 188: 2905-13 (2012).
- Yang, IV, Alper, S, Lackford, B, Rutledge, H, Burch, LH, and Schwartz, DA. Novel Regulators of the Systemic Response to Lipopolysaccharide (LPS). American J. Resp. Cell. Mol. Biol. 45: 393-402. (2011).