Schwartz/Yang Lab: Publications

Selected Pulmonary Fibrosis Publications

• Seibold MA, Schwartz DA. The lung: the natural boundary between nature and nurture. Annu Rev Physiol. 2011 Mar 17;73:457-78.
• Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, Evans CM, Garantziotis S, Adler KB, Dickey BF, du Bois RM, Yang IV, Herron A, Kervitsky D, Talbert JL, Markin C., Park J, Crews AL, Slifer SH, Auerbach S, Roy MG, Lin J, Hennessy CE, Schwarz MI, and Schwartz DA. A common polymorphism in the putative promoter of MUC5B is associated with familial interstitial pneumonia (FIP) and idiopathic pulmonary fibrosis (IPF). N Engl J Med. 364:1503-1512 (2011).
• Boon K, Bailey NW, Yang, J, Steele MP, Groshong S, Yang J, Kervitsky D, Brown KK, Schwarz MI, Schwartz DA. Molecular phenotypes distinguish patients with relatively stable from progressive Idiopathic Pulmonary Fibrosis (IPF). PLoS ONE 2009; 4:e5134. Abstract
• Garantziotis S, Zudaire E, Trempus CE, Hollingsworth JW, Jiang D, Lancaster LH, Richardson E, Zhuo L, Cuttitta F, Brown KK, Noble PW, Kimata K, Schwartz DA. Serum inter-alpha-trypsin inhibitor and matrix hyaluronon promote angiogenesis in fibrotic lung injury. Am J Resp Crit Care Med 2008; 178:939-947. Abstract
• Yang IV, Burch LH, Steele MP, Savov JD, Hollingsworth JW, McElvaniaTekippe E, Berman KG, Speer MC, Sporn TA, Brown KK, Schwarz MI, Schwartz DA. Gene Expression Profiling of Familial and Sporadic Cases of Interstitial Pneumonia. Am J Resp Crit Care Med 2007; 175:45-54. Abstract
• Steele MP, Speer MC, Loyd JE, Brown KK, Herron A, Slifer SH, Burch LH, Phillips JA, Sporn TA, McAdams HP, Schwarz MI, Schwartz DA. Clinical and pathologic features of familial interstitial pneumonia (FIP). Am J Resp Crit Care Med 2005; 172:1146-1152. Abstract

Selected Innate Immunity Publications

• Yang IV, Rutledge H, Yang J, Warg LA, Sevilla S, Schwartz DA. A Locus on Chromosome 9 is Associated with Differential Response of 129/SvIm and FVB/NJ Strains of Mice to Systemic LPS. Mammalian Genome. In press.
• Yang IV, Jiang W, Rutledge HR, Lackford B, Alper S, Schwartz DA, Pisetsky DS. Molecular Pathways and Transcriptional Networks Induced in RAW264.7 Macrophage Cells by Stimulation with TLR Ligands. Molecular Immunology. In press.
• Yang IV, Alper S, Lackford B, Rutledge H, Warg LA, Burch LH, Schwartz DA. Novel regulators of the systemic response to lipopolysaccharide (LPS). Am J Respir Cell Mol Biol. In press.
• Rutledge HR, Jiang W, Yang J, Warg LA, Schwartz DA, Pisetsky, DS, Yang IV. Gene expression profiles of RAW264.7 macrophages stimulated with preparations of lipopolysaccharide (LPS) differing in isolation and purity. Innate Immunity. In press.
• Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SNP, Collins F, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY., McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, Pardo-Manuel de Villena F, Churchill GA. Genetic Analysis of Complex Traits in the Emerging Collaborative Cross. Genome Res. In press.
• Lei J, Liang-guo X, Yang IV, Davidson EJ, Schwartz DA, Wurfel MM, Cambier JC. Identification and characterization of a loss-of-function human MPYS variant. Genes and Immunity. 2011;12:263-9.
• Yang IV, Wade CM, Kang HM, Alper S, Rutledge H, Lackford B, Eskin E, Daly MJ, Schwartz DA. Identification of novel genes that mediate innate immunity using inbred mice. Genetics. 2009; 183:1535-44. Abstract
• Zaas AK, Liao G, Chien J, Weinberg C, Shore D, Giles SS, Marr KA, Usuka J, Burch L, Perara L, Perfect JR, Schwartz DA. Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis. PLOS Genetics 2008; 4:e1000101. Abstract
• Alper S, Laws R, Lackford B, Boyd WA, Dunlap P, Freedman JH, Schwartz DA. Identification of innate immunity genes and pathways using a comparative genomics approach. Proc Nat Acad Sciences 2008; 105:7016-7021. Abstract
• Hollingsworth JW, Maruoka S, Li Z, Potts EN, Foster WM, Schwartz DA. Ambient ozone primes pulmonary innate immunity in mice. J Immunology 2007; 179:4367-4375. Abstract
• Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol 2004; 5:975-979. Abstract
• Cook, DN, Wang S, Wang Y, Howles GP, Whitehead GS, Berman K, Church TD, Frank B, Gaspard R, Yu Y, Quackenbush J, Schwartz DA. Genetic regulation of endotoxin-induced airway disease. Genomics 2004; 83:961-969. Abstract
• Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis in humans. N Engl J Med 2002; 347:185-192. Abstract
• Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutation is associated with endotoxin hyporesponsiveness in humans. Nature Genetics 2000; 25:187-191. Abstract

Selected Asthma Epigenetics Publications

• Schwartz DA. Epigenetics and environmental lung disease. Proc Am Thorac Soc. 2010 May;7(2):123-5. Review.
• Yang IV and Schwartz DA. Epigenetic Control of Gene Expression in the Lung. Am. J. Resp. Crit. Care Med. 183:1295-1301 (2011).
• Boon K, Tomfohr JK, Bailey NW, Garantziotis S, Li Z, Brass DM, Maruoka S, Hollingsworth JW, Schwartz DA. Evaluating genome-wide DNA methylation changes in mice by Methylation Specific Digital Karyotyping. BMC Genomics 2008; 9:598. Abstract
• Hollingsworth JW, Maruoka S, Boon K, Brass DM, Tomfohr J, Garantziotis S, Li Z, Bailey N, Potts E, Schwartz DA. In utero supplementation with methyl-donors enhances allergic airway disease in mice. J Clin Invest 2008; 118:3462-3469. Abstract