Figure 1. In the area of genetic variation, we are using next generation sequencing and genotyping to identify polymorphisms in genomic sequences. In one project, we are sequencing whole genomes from clinically relevant pathogenic micro-organisms to identify single nucleotide polymorphisms (snps), insertions and deletions, genomic duplications, and genomic rearrangements that may contribute to phenotypic traits ranging from increased virulence to drug resistance. In another project, we are resequencing targeted areas of the genome in a large cohort of asthmatic subjects to identify rare variants that explain their varied response to a common asthma medication.
Lung Genomics Research Consortium
This multi-center Consortium uses advanced genetic and molecular tools to characterize and better understand COPD and pulmonary fibrosis.
Familial Pulmonary Fibrosis Research
National Jewish Health has teamed with Duke University and Vanderbilt University to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis.
NTM Center for Excellence
The Nontuberculous Mycobacteria (NTM) Center of Excellence is comprised of National Jewish Health physicians and researchers dedicated to enhancing the clinical care for all patients with NTM infections, and expanding the body of knowledge on NTM through translational research.