Figure 1. Three types of epigenetic modification that regulate gene expression in mammalian cells.
(A) Methylation of DNA cytosine residues at the carbon 5 position (5meC) is a common epigenetic mark in many eukaryotes and is most often found in CpG sequence context. When located at gene promoters, DNA methylation is usually association with repression of gene expression.
(B) Histone proteins are subject to a number of covalent modifications, primarily at their N-terminal tails, including methylation, acetylation, phosphorylation, ubiquitylation and ADP-ribosylation. These modifications lead to either repression or enhancement of gene expression.
(C) Gene regulation by transcription factors and microRNAs. One or more transcription factors activate transcription by binding to cis-regulatory sites, which are commonly situated upstream of protein-coding genes. After transcription, one or more microRNAs bind to cis-regulatory sites, usually in the 3' UTR of the mRNA, and repress protein translation4.
Lung Genomics Research Consortium
This multi-center Consortium uses advanced genetic and molecular tools to characterize and better understand COPD and pulmonary fibrosis.
Familial Pulmonary Fibrosis Research
National Jewish Health has teamed with Duke University and Vanderbilt University to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis.
NTM Center for Excellence
The Nontuberculous Mycobacteria (NTM) Center of Excellence is comprised of National Jewish Health physicians and researchers dedicated to enhancing the clinical care for all patients with NTM infections, and expanding the body of knowledge on NTM through translational research.