Alper Lab: Selected Publications

Alper, S, McBride, S, Lackford, B, Freedman, JH, and Schwartz, DA. Specificity and Complexity of the C. elegans Innate Immune Respone. Mol. Cell. Biol. 27: 5544-5553 (2007).

Alper, S, Laws, R, Lackford, B, Boyd, WA, Dunlap, P, Freedman JH, and Schwartz, DA. Identification of Novel Innate Immunity Genes and Pathways Using a Comparative Genomics Approach. Proc. Natl. Acad. Sci. USA. 105: 7016-7021. (2008).

Alper, S, Mcelwee, M, Apfeld, J, Lackford, B, Freedman, JH, and Schwartz, DA. The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity. J. Biol. Chem. 285: 1822-1828. (2010).

De Arras, L, Yang, IV, Lackford, B, Riches, DWH, Prekeris, R, Freedman, JH, Schwartz, DA, and Alper, S. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J. Immunol. 188: 2905-13 (2012).

Victorino, F, and Alper, S. Identifying novel spatiotemporal regulators of innate immunity. Immunologic Research. 55: 3-9 (2013).

De Arras, L, Seng, A, Lackford, B, Keikhaee, MR, Bowerman, B, Freedman, JH, Schwartz, DA, Alper, S. An evolutionarily conserved innate immunity protein interaction network. J. Biol. Chem. 288: 1967-1978 (2013).

De Arras, L and Alper, S. Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing. PLOS Genetics 9(10):e1003855 (2013).

De Arras, L, Laws, R, Leach, S, Pontis, K, Freedman, JH, Schwartz, DA and Alper, S. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. Genetics 197: 485-496 (2014).

De Arras, L, Guthrie, BS and Alper, S. Using RNAi-interference to investigate the innate immune response in mouse macrophages. J. Vis. Exp. 93:e51306 (2014).

O’Connor, BP, Danhorn, T, De Arras, L, Flatley, BR, Marcus, RA, Farias-Hesson, E, Leach, SM and Alper, S. Regulation of Toll-like receptor signaling by the SF3a mRNA splicing complex. PLOS Genetics. 11(2):e1004932 (2015).