Alper Lab: Publications
Alper, S, McBride, S, Lackford, B, Freedman, JH, and Schwartz, DA. Specificity and Complexity of the C. elegans Innate Immune Respone. Mol. Cell. Biol. 27: 5544-5553 (2007).
Cui, Y, McBride SJ, Boyd, WA, Alper, S, and Freedman, JH. Toxicogenomic Analysis of Caenorhabditis elegans Reveals Novel Genes and Pathways in the Resistance to Cadmium Toxicity. Genome Biol. 8: R122 (2007).
Alper, S, Laws, R, Lackford, B, Boyd, WA, Dunlap, P, Freedman JH, and Schwartz, DA. Identification of Novel Innate Immunity Genes and Pathways Using a Comparative Genomics Approach. Proc. Natl. Acad. Sci. USA. 105: 7016-7021. (2008).
Yang, IV, Wade, CM, Kang, HM, Alper, S, Rutledge H, Lackford B, Eskin, E., Daly, MJ, and Schwartz DA. Identification of novel genes that mediate innate immunity in inbred mice. Genetics. 183: 1535-1544. (2009).
Green, RM, Gally, F, Keeney, JG, Alper, S, Gao, B, Han, M, Martin, RJ, Weinberger, AR, Case, SR, Minor, MN, Chu, HW. Impact of cigarette smoke exposure on innate immunity: a Caenorhabditis elegans model. PLOS One. 4:e6860. (2009).
Alper, S, Mcelwee, M, Apfeld, J, Lackford, B, Freedman, JH, and Schwartz, DA. The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity. J. Biol. Chem. 285: 1822-1828. (2010).
Alper, S. Model Systems to the Rescue: the relationship between aging and innate immunity. Comm. and Integr. Biol. 3(5): 409-414. (2010).
Yang, IV, Alper, S, Lackford, B, Rutledge, H, Burch, LH, and Schwartz, DA. Novel Regulators of the Systemic Response to Lipopolysaccharide (LPS). American J. Resp. Cell. Mol. Biol. 45: 393-402. (2011).
Yang, IV, Jiang, W, Rutledge, HR, Lackford, B, Warg, LA, De Arras, L, Alper, S, Schwartz, DA, and Pisetsky, DS. Identification of Novel Innate Immune Genes by Transcriptional Profiling of Macrophages Stimulated with TLR Ligands. Molec Immunol. 48: 1886-95 (2011).
De Arras, L, Yang, IV, Lackford, B, Riches, DWH, Prekeris, R, Freedman, JH, Schwartz, DA, and Alper, S. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J. Immunol. 188: 2905-13 (2012).
Victorino, F, and Alper, S. Identifying novel spatiotemporal regulators of innate immunity. Immunologic Research. 55: 3-9 (2013).
De Arras, L, Seng, A, Lackford, B, Keikhaee, MR, Bowerman, B, Freedman, JH, Schwartz, DA, Alper, S. An evolutionarily conserved innate immunity protein interaction network. J. Biol. Chem. 288: 1967-1978 (2013).
De Arras, L and Alper, S. Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing. PLOS Genetics 9(10):e1003855 (2013).
De Arras, L, Laws, R, Leach, S, Pontis, K, Freedman, JH, Schwartz, DA and Alper, S. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. Genetics published online Dec 20 (2013).
De Arras, L and Alper, S. Using RNAi-interference to investigate the innate immune response in mouse macrophages. J. Vis. Exp. in press (2013).