Strong Laboratory

Michael Strong, PhD We are interested in developing and applying computational and molecular methods to better generate, integrate and analyze genomic and proteomic information, with a focus on respiratory diseases and disease pathogens, including Mycobacterium tuberculosis. M. tuberculosis, the causative agent of the human tuberculosis disease, results in approximately 1.6 million deaths each year, most of which occur in developing countries. Our work falls under the general categories of systems biology, genomics, computational biology, and structural informatics, and builds on disciplines ranging from microbiology to genetics to computer science.

Our group is particularly interested in the interplay among humans, their pathogens and environmental factors. Many diseases occur as a result of a complex interplay among human genetic factors, human-pathogen interactions and environmental stimuli, and it is our goal to better understand these relationships through the integration and analysis of large-scale biological and genomic datasets. We have active projects and collaborations that include complete genome sequencing, gene expression analysis, protein and gene network analysis and structural informatics.

We are also very interested in developing computational methods that can help our clinical counterparts, particularly in areas related to gene-based diagnostics and drug resistance. Since our group is centered at National Jewish Health, one of the premier respiratory hospitals in the United States, we draw on the strength of both our clinicians and basic scientists, in order to apply modern genomic and bioinformatic strategies to address important areas of respiratory disease research. We are also very interested in international collaborations, particularly with individuals working in developing countries most affected by devastating global diseases such as tuberculosis, malaria and AIDS, where the medical need often outweighs the available resources.

Learn about our lab collaborators and open positions.

For more information on the Strong Laboratory, please visit www.stronglab.org.

 

Current Projects

Traditional Protein Network

Personnel

 

Contact Information

Dr. Michael Strong
National Jewish Health
Integrated Center for Genes, Environment and Health
Smith Building, Room A656
1400 Jackson Street
Denver, CO 80206

Office Phone: 303.270.2782

email: StrongM@NJHealth.org

Publications

  • Sandgren A, Strong M, Mutukrishnan P, Weiner BK, Church GM, Murray MB. Tuberculosis Drug Resistance Mutation Database. PLoS Medicine 2009; 6:2. Abstract
  • Strong M, Eisenberg D. The Protein Network as a Tool for Finding Novel Drug Targets.  Progress in Drug Research 2007; 64:193-215.  Abstract

More Publications

 

Lung Genomics Research Consortium

This multi-center Consortium uses advanced genetic and molecular tools to characterize and better understand COPD and pulmonary fibrosis.
Learn more.

 

Familial Pulmonary Fibrosis Research

National Jewish Health has teamed with Duke University and Vanderbilt University to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis.
Learn more.

 

NTM Center for Excellence

The Nontuberculous Mycobacteria (NTM) Center of Excellence is comprised of National Jewish Health physicians and researchers dedicated to enhancing the clinical care for all patients with NTM infections, and expanding the body of knowledge on NTM through translational research.

Learn more.

Integrated Center for Genes, Environment & Health

This is an interdisciplinary program dedicated to understanding the genetics of complex lung and immune-related conditions common in patients cared for at National Jewish Health. Learn more.