Figure 1. Effects of ozone on the lung. O3 can disrupt epithelial tight junctions and mucociliary clearance and can induce production of proinflammatory factors. O3 is directly cytotoxic to macrophages. O3 can modify macrophage phagocytosis, intracellular killing, and levels of secreted factors. O3 can impair neutrophil phagocytosis and intracellular killing.
Adapted from Hollingsworth. Proc Am Thorac Soc Vol 4. pp 240–246, 2007.
Lung Genomics Research Consortium
This multi-center Consortium uses advanced genetic and molecular tools to characterize and better understand COPD and pulmonary fibrosis.
Familial Pulmonary Fibrosis Research
National Jewish Health has teamed with Duke University and Vanderbilt University to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis.
NTM Center for Excellence
The Nontuberculous Mycobacteria (NTM) Center of Excellence is comprised of National Jewish Health physicians and researchers dedicated to enhancing the clinical care for all patients with NTM infections, and expanding the body of knowledge on NTM through translational research.