My major research focus is on pharmacotherapy of childhood asthma and predicting response to asthma therapy.
I am the Principal Investigator for the Denver Site of the NHLBI AsthmaNet clinical research network. This multicenter collaborative network designs and conducts studies to address major issues of therapeutic intervention in childhood and adult asthma. Our site has lead a series of studies addressing significant clinical questions on the use of inhaled glucocorticoids in the treatment of asthma including patient phenotypes and genotypes associated with various degrees of response.
I am also a co-investigator for the Denver Site of the NIAID Inner City Asthma Consortium. I lead a protocol on the effect of therapeutic interventions to prevent asthma exacerbations that occur in the fall season. I am the Director of our center's site for a Colorado State Cardiovascular, Cancer and Pulmonary Disease Grant that focuses on asthma in the Denver Public School system. Our program is a combined epidemiology and case management program designed to help reduce school absence due to asthma.
Our research group also investigates asthma progression, early infant asthma and the management of severe childhood asthma.
Childhood asthma; Asthma pharmacotherapy; Inhaled corticosteroids; Biomarkers; Predictors of treatment response; Monitoring treatment response.
Szefler SJ. Advances in Pediatric Asthma in 2011: Moving forward. J Allergy Clin Immunol 2012; 129:60-68. PMC 3032272; NIHMS 256545.
Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, Kita H, Liu AH, Penettieri RA, Schleimer RP, Minnicozzi M. Asthma outcomes: biomarkers. J Allergy Clin Immunol 2012;129;S9-23.
Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleeker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA. Comparison of Physician-Based, Biomarker-Based, and Symptom-Based Strategies for Adjustment of Inhaled Corticosteroid Therapy in Adults with Asthma: The Basalt Randomized Trial. JAMA, 2012;308:987-997.
Chipps BE. Zeoger RS, Borish L, Wenzel SE, Yegin A, Hayden ML, Miller DP, Bleecker ER, Simons FER, Szefler SJ, Weiss ST, Hasselkorn T. Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol, 2012;130:332-42.
Zeiger RS, Mauger D, Bacharier LB, Guilbert TW, Martinez FD, Lemanske RF, Strunk RC, Covar R, Szefler SJ, Boehmer S, Jackson DJ, Sorkness CA, Gern JE, Kelly HW, Friedman NJ, Mellon MH, Schatz M, Morgan WJ, Chinchilli VM, Raissy HH, Bade E, Malka-Rais J, Beigelman A, Taussig LM for the Childhood Asthma Research and Education Network of the National Heart, Lung and Blood Institute. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med 2011;365:1990-2001.