- Computational Biology
- Genomic Data Integration
- Probabilistic Graphical Models
- Proteomics, Metabolomics
- Translational Research
Education & Training
- Brown University, PhD
Dr. Leach's responsibilities at the Integrated Center for Genes, Environment, and Health are to develop computational algorithms for the analysis and interpretation of genomic and proteomic datasets. She is particularly interested in methods which integrate diverse types of genomic data in order to explain high-throughput data results and prioritize those results for further follow-up studies.
Affiliations with the University of Colorado Denver
Assistant Professor, Computational Bioscience Program, University of Colorado Denver
Yang IV, Luna LG, Cotter J, Talbert J, Leach SM, Kidd R, Turner J, Kummer N, Kervitsky D, Brown KK, Boon K, Schwarz MI, DA, Steele MP. "The Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis", PLoS ONE. 2012, 7(6):e37708. PMCID:PMC3382229
Bin L, Kim BE, Hall CF, Leach SM, Leung DYM, Inhibition of Transcription Factor Specificity Protein 1 Alters the Gene Expression of Keratinocytes Leading to Up-regulation of Kallikrein-related Peptidases and TSLP, Journal of Investigative Dermatology, 2011, Nov;131(11):2213-22. PMCID: PMC3193562
Yu S, Tranchevent L, Leach SM, De Moor B, Moreau Y. A kernel based framework for cross-species candidate gene prioritization, Machine Learning in Systems Biology, 2011.
Feng W, Leach SM, Tipney H, Phang T, Geraci M, Spritz R, Hunter L, Williams T. Spatial and Temporal Analysis of Gene Expression During Growth and Fusion of the Mouse Facial Prominences. PLoS ONE. 2009; 4(12): e8066. PMCID: PMC2789411
Leach SM, Tipney H, Feng W, Baumgartner WA, Kasliwal P, Schuyler RP, Williams T, Spritz RA, Hunter L. Biomedical Discovery Acceleration, with Applications to Craniofacial Development. PLoS Comput Bio, 2009, 5(3):e1000215. PMCID: PMC2653649