Faculty Bio Detail

Stijn P. De Langhe

Stijn P. De Langhe, PhD

  • Assistant Professor
  • Department of Pediatrics

Profile

Research Areas

  • Asthma
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Pulmonary Disease Research, Other
  • Pulmonary Fibrosis
  • Stem Cells
Gender:
Male

Education & Training

Education

1998
Ghent University (Belgium), MS, Biotechnology/Biochemistry
2005
Ghent University (Belgium)/Childrens Hospital Los Angeles, PhD, Biotechnology

Fellowship

2005-2007
Childrens Hospital Los Angeles/USC Keck School of Medicine

Special Interests

Research Interests

Our group focuses on lung development, lung regeneration and lung stem cells. We are especially interested in how Wnt and FGF signaling pathways between stem cells and their niche control the differentiation, proliferation and maintenance of several mesenchymally and epithelial cell lineages.

Affiliations with the University of Colorado Denver

Assistant Professor, Department of Cell and Developmental Biology

Program in Cell Biology, Stem Cells and Developmental Biology

Publications

De Langhe, S.P., Carraro, G., Tefft, D., Li, C., Xu, X., Chai, Y., Minoo, P., Hajihosseini, M.K., Drouin, J., Kaartinen, V., et al. (2008). Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE 3, e1516.

De Langhe, S.P., Carraro, G., Warburton, D., Hajihosseini, M. K., and Bellusci, S. (2006). Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299, 52-62.

del Moral,P.M., De Langhe,S.P., Sala,F.G., Veltmaat,J.M., Tefft,D., Wang,K., Warburton,D., and Bellusci,S. (2006). Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev. Biol. 293, 77-89.

Mailleux,A.A., Kelly,R., Veltmaat,J.M., De Langhe,S.P., Zaffran,S., Thiery,J.P., and Bellusci,S. (2005). Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132, 2157-2166.

De Langhe,S.P., Sala,F.G., del Moral,P.M., Fairbanks,T.J., Yamada,K.M., Warburton,D., Burns,R.C., and Bellusci,S. (2005). Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev. Biol. 277, 316-331.

Office Information

Doctor's Contact Information

  • Office: 303.398.1763
  • Email: delanghes@njhealth.org

Locations

  • Main Campus
    1400 Jackson St.
    Denver, CO 80206
    Main: 877.225.5654