- Basic Immunology
- Diabetes, Type-1
Education & Training
- University of Kansas (Lawrence, KS), PhD, Biochemistry
- National Jewish Health, Postdoctoral Fellowship in Immunology
T cell immunology, autoimmunity, type 1 diabetes. Our research is focused on the mechanisms and regulation of pathogenesis in the NOD mouse model of type 1 diabetes (T1D). We use cloned T cell lines and TCR transgenic mice to study the disease process. Our goals are to acquire better understanding of how CD4 T cells contribute to pathogenesis in T1D, investigate the beta cell autoantigens that activate autoreactive T cells, and develop new strategies for inducton of tolerance and prevention of disease.
Affiliations with the University of Colorado Denver
Professor, Department of Immunology
AAI, American Diabetes Association, Immunology of Diabetes Society
Haskins, K. 2005. Pathogenic T cell clones in autoimmune diabetes: more lessons from the NOD mouse. Advances in Immunol. 87: 123-62.
Cantor, J. and Haskins, K. (2005) Effector Function of Diabetogenic CD4 Th1 T cell clones: A Central Role for TNFa. J. Immunol. 175: 7738-45.
Cantor, J. and Haskins, K. (2007) Recruitment and activation of macrophages by pathogenic CD4 T cells in T1D: Involvement of CCR8 and CCL1. J. Immunol. 179: 5760-67. Tonkin, D.R., He, J., Barbour, G. and Haskins, K. 2008. Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J. Immunol. 181: 4516-22
Tonkin, D.R. and Haskins, K. 2009. Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-ß-dependent manner. Eur. J. Immunol. 39: 1313-22.
Stadinski, B.D.*, Delong, T.*, Reisdorph, N., Reisdorph, R., Powell, R.L., Armstrong, M., Piganelli, J.D., Barbour, G., Bradley, B., Crawford, F., Marrack, P., Mahata, S.K., Kappler, J.W. and Haskins, K. 2010. Chromogranin A is an autoantigen in type 1 diabetes. Nature Immunology 11: 225-31.
*Denotes equal contributions.
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Link to Faculty Publications