QIL: Research Projects

Our research arm has a pivotal role in the development and evaluation of new quantitative modalities, some of which can be translated into the clinical realm in relatively short time frames. The QIL research arm will provide support for the activities of clinical researchers based at National Jewish Health, and elsewhere, to characterize new phenotypes of disease and develop innovative and more sophisticated methods for image analysis. In its two years of operation, the QIL has already demonstrated several important potential applications of these technologies in the characterization of COPD and in the monitoring of individuals with severe asthma. Additionally, we have established partnerships with industry leaders Siemens and VIDA, Inc.

Our current projects include:

 

Childhood Asthma Management Program (CAMP)
CAMP is a National Heart, Lung and Blood Institute sponsored research program designed to evaluate the effect of three different treatment strategies on lung growth.

 

COPDGENE Project
The COPDGene® Study is one of the largest studies ever to investigate the underlying genetic factors of Chronic Obstructive Pulmonary Disease or COPD.

In the COPDGene project, we are using phenotypic characterization of COPD subjects using CT images, together with clinical and physiological measures, to classify the broad COPD syndrome into clinically significant subtypes. We concluded that quantitative CT can be used to identify three distinct components of COPD (emphysema, air trapping and airway wall thickening) and that quantitative CT measurements of these COPD features are significantly associated with physiologic airway obstruction.

 

NIH Molecular Phenotyping Genome Project
(Grant awarded to David Schwartz, MD)
The overall goal of the molecular phenotyping project is to combine genetic and genomic findings in patients with idiopathic interstitial pneumonia (IIP) to develop and validate phenotypically-anchored molecular signatures that serve to refine the diagnostic criteria for this group of complex diseases.

 

IPFNet
The study's goal is to find effective therapies for patients with both the early and advanced stages of idiopathic pulmonary fibrosis (IPF). We are also involved with two sub-studies; PANTHER and ACE.

 

Siemens Medical Solutions Inc.
1. COPDGene analysis grant - This study uses quantitative CT scanning in cigarette smokers with and without COPD to determine differences between these groups in % emphysema, % air trapping, and segmental and subsegmental airway wall thickness.

2. Evaluation of Lung Nodules in Patients with COPD - This study will use PET/CT to characterize small nodules in lungs.

 

Learn more about some of our research collaborations with the Schwartz Laboratory.