Drug Susceptibility Testing for Tuberculosis
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National Jewish Health Mycobacteriology Laboratory provides comprehensive drug susceptibility testing for tuberculosis (antimicrobial), including M. tuberculosis complex and mycobacterium avium complex.
Tuberculosis Drug Susceptibility Testing Methods
- Molecular line-probe assay/MDR TB screen for rifampin and isoniazid (INH).
- Molecular line-probe assay/XDR TB screen for fluoroquinolones and aminoglycosides/cyclic peptides (XDR TB). The assay testing allows also for ethambutol resistance.
- Isoniazid, rifampin and ethambutol testing performed in a non-radiometric macrodilution assay using critical concentrations. For pyrazinamide we perform MICs. MICs also are available for isoniazid, rifampin and ethambutol upon request.
- Isoniazid, rifampin, ethambutol , ethionamide, streptomycin, capreomycin, kanamycin, amikacin, cycloserine and para-aminosalicylic acid (PAS) testing is performed using Middlebrook 7H11 agar proportion method.