Drops May Bring Relief to Allergy Patients

Immunotherapy, also known as allergy shots, is one of the most effective allergy treatments. Repeatedly injecting an allergen under the skin actually alters the immune system so that it no longer reacts to pollen and other allergens. Immunotherapy begins having a positive effect for most people soon after shots begin and is usually effective for many years after shots have been completed.

The main drawback to immunotherapy is that patients have to visit a doctor’s office repeatedly for three to five years in order to get their shots. This has significantly limited its appeal and use. National Jewish allergist Harold Nelson, M.D., is beginning a trial of immunotherapy drops that can be placed under the tongue instead. This is a safer method of immunotherapy, with minimal risk of severe reaction. Thus, they could be administered at home, which could make immunotherapy a more attractive option for many more allergy sufferers.

Allergy drops have been used for several years in Europe. Several trials are currently evaluating allergy drops for possible approval in the United States. However, in Europe and in most of the U.S. trials, allergy drops include only one allergen. Most people are allergic to several allergens, from various pollens to dust mites and animal dander. That is why most American immunotherapy solutions contain several different allergens. Dr. Nelson’s trial will evaluate allergy drops containing several different allergens to see if they are effective as well.

For more information and possible participation in this and other clinical trials at National Jewish, contact the Adult Clinical Research Unit at 303.398.1911 or Pediatric Research at 303.270.2222. You also may search National Jewish clinical trials online.