The medicine Buproprion SR (Zyban or Wellbutrin) is a prescription quit smoking aid. Read the information below and talk to your doctor about Buproprion to see if it is appropriate for you.

Buproprion SR  does not contain nicotine. It is a tablet that you take by mouth once or twice a day. It should be started one to two weeks  before your Quit Date. When taken every day, it helps to lessen your desire to smoke. Once you quit, it reduces the severity of cravings and withdrawal symptoms. Before your Quit Date, talk to your doctor about Buproprion SR and if it is appropriate for you. Your doctor will advise you about how to take this medicine. Some people will begin with a single dose every morning for three days, then increase to twice daily. Most people use Buproprion SR for seven to twelve weeks. The most common side effects are trouble sleeping and dry mouth.

Buproprion SR is not recommended if you have a history of seizures, eating disorder, for those taking another form of Bupropion or those who have used an MAO inhibitor in the past 14 days.



Fiore MC, Jaén CR, Baker TB, et al. Treating Tobacco Use and Dependence:  2008 Update.  Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. May 2008.


This information has been approved by Amy Lukowski, PsyD (October 2010).

Bookmark and Share