- Airway Epithelial Cell Biology
- Chronic Obstructive Pulmonary Disease (COPD)
- Respiratory bacterial and viral infections in asthma and COPD
Airway epithelial cell host defense functions against bacterial and viral infections in asthma and COPD.
Dr. Chu’s laboratory studies the innate immunity of lung cells such as epithelial cells and macrophages in asthma and COPD. Particularly, Dr. Chu focuses on revealing the mechanisms underlying the increased susceptibility to respiratory infections of bacteria and viruses in airways of asthma and COPD patients.
Affiliations with the University of Colorado Denver
Zhang W, Case S, Bowler RP, Martin RJ, Jiang D, Chu HW. Cigarette smoke modulates PGE2 and host defense against Moraxella catarrhalis infection in human airway epithelial cells. Respirology 2011;16:508–516. PMID: 21199162
Wu Q, Jiang D, Minor MN, Martin RJ, Chu HW. In vivo function of airway epithelial TLR2 in host defense against bacterial infection. Am J Physiol Lung Cell Mol Physiol 2011;300:L579–586. PMID: 21239529
Simon GC, Martin RJ, Smith S, Thaikoottathil J, Bowler RP, Barenkamp SJ, Chu HW. Up-regulation of MUC18 in Airway Epithelial Cells by IL-13: Implications inBacterial Adherence. Am J Respir Cell Mol Biol 2011;44:606–613. PMID: 21239604
Gally F, Di YP, Smith SK, Minor MN, Liu Y, Bratton DL, Frasch SC, Michels NM, Case SR, Chu HW. SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol 2011;178:2159–2167. PMID: 21514430
Case SR, Martin RJ, Jiang D, Minor MN, Chu HW. MicroRNA-21 inhibits TLR2 agonist-induced lung inflammation in mice. Exp Lung Res 2011, in press.