- Autoimmune Lung Diseases
- Chronic Cough
- Cellular and Molecular Biology
Education & Training
- Massachusetts Institute of Technology, BS, Mathematics
- University of Washington, MD, PhD
- University of California, San Francisco, Internal Medicine
- University of California, San Francisco, Pulmonary and Critical Care
The glucocorticoid receptor is one of the most important therapeutic targets for the treatment of inflammatory disorders of the lung such as asthma. My laboratory investigates two aspects of glucocorticoid receptor signaling. First, we are studying the basic molecular mechanisms whereby glucocorticoids repress the expression of inflammatory genes in airway smooth muscle. Second, we are investigating how various non-inflammatory genes that are regulated by glucocorticoids alter lung function. By defining new mechanisms of glucocorticoid action we ultimately seek to discover new targets for asthma therapeutics.
Teaching or Professional Positions
No current positions.
Industry Relationships & Collaborations
National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.
Affiliations with the University of Colorado Denver
Assistant Professor of Medicine
Graduate Faculty, Department of Pharmacology
American Thoracic Society
American Physiological Society
American Lung Association of Colorado
Sasse SK, Mailloux C, Barczak A, Wang Q, Altonsy O, Jain MK, Haldar SM and Gerber AN. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed forward circuitry. Mol Cell Biol. 2013 Mar 18. [Epub ahead of print]
Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6739-44
Gerber A.N., Sutherland ER. Vitamin d and asthma: another dimension (Review). Am J Respir Crit Care Med. 2011 Dec 15;184(12):1324-5. PMID: 2217410
Masuno K, Haldar SM, Jeyaraj D, Mailloux C, Huang X, Panettieri Jr RA, Jain MK, Gerber A.N. 2011 Expression profiling identifies Klf15 as a glucocorticoid target that regulates Airway Hyperresponsiveness. Am J Respir Cell Mol Biol. 2011. Sep;45(3):642-9 PMCID: 21257922
Gerber, A.N., Masuno K., Diamond M.I. 2009. Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4929-34.