Research Areas
- Cancer
- Cell Signaling
- Cellular and Molecular Biology
- Epithelial Cell Biology
- Genomics
- Inflammation
- Lung Cell Biology
- Gender:
- Male
Education & Training
Education
- 1979
- University of Wisconsin (Madison, WI), MD
Residency
- 1979-1982
- University of Texas Southwestern, Parkland Memorial Hospital (Dallas, TX), Internal Medicine
Fellowship
- 1982-1984
- Hospital of the Univerisity of Pennsylvania, Pulmonary, Critical Care
Special Interests
Research Interests
Dr. Kern is an expert in how cells in the lung grow, focusing on a family of proteins that regulate cell growth by transmitting signals outside the cell to the inside. These proteins play an important role in keeping a cell’s growth in check. When these proteins misfunction, abnormal growth ensues which can result in lung cancer. Dr. Kern’s research tries to understand how these protein signals are regulated, discover molecules that interfere with this process and might be used as chemotherapy, and discover new proteins regulating cell growth.
Board Certification
Internal Medicine
Pulmonary Medicine
Teaching or Professional Positions
2000-2009: Former Chief, Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University
Professional Memberships
American Thoracic Society, Member
American College of Chest Physicians, Fellow
Ohio Thoracic Society
Central Society for Clinical Research
American Association for the Advancement of Science
American Association of Cancer Research
Awards & Recognition
2011, 2012: America's Top Docs by US news and World Report
2010-Present: Scientific Advisory Board, Cancer League of Colorado
1996-2010: “Best Doctor," selected by Best Doctors, Boston, MA
2008-2009: Editorial Board of Translational Research
2000-2009: Hubbell Chair in Pulmonary and Critical Care Medicine
2006, 2007: “Top Physician” selected by the Consumer Research Council of America
Elected by peers for inclusion in the Best Doctors in America® since 1996 in Pulmonary and Critical Care
Publications
Kluge A, Dabir S, Kern J, Nethery D, Halmos B, Ma P, Dowlati A. Cooperative Interaction between Protein Inhibitor of Activated STAT3 with EGFR blockade in Lung Cancer. Int J Cancer. 2009 Oct 1;125(7):1728-34
Kolosova, I, Nethery, D, Kern, JA. Role of Smad2/3 and p38 MAP kinase in TGF-?1-induced epithelial-mesenchymal transition of pulmonary epithelial cells. J Cell Physiol, 2011; 226:1248-54. doi: 10.1002/jcp.22448. PMID: 20945383
Finigan, JH, Faress, JA, Wilkinson, E, Mishra, R, Nethery, DE, Wyler, D, Shatat, M, Ware, LB, Matthay, MA, Mason, R, Silver, RF, Kern, JA. Neuregulin-1-HER2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. J. Biol Chem. 2011 Mar 25;286(12):10660-70, PMID: 21247898
Finigan, JH, Mishra, R, Vasu, VT, Silveira, LJ, Nethery, DE, .Standiford, TJ, Burnham, EL, Moss, M, Kern, JA. Broncho-alveolar lavage neuregulin-1 is elevated in patients with acute lung injury and correlates with ventilator free days. (In Press, Eur Resp J 2012)
Finigan, JH, Downey, G, Kern, JA. HER receptor signaling in acute lung injury. (In Press, Am J Resp Cell Mol Bio, 2012)
More Publications by This Author
Link to Faculty Publications
Link to PubMed for more papers
