Research Areas
- Acute Lung Injury
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
- Innate Immunity of the Lung
- Interstitial Lung Disease (ILD)
- Viral Infections
- Gender:
- Female
Education & Training
Education
- 1990
- Yamagata University School of Medicine (Yamagata, Japan), MD
- 1997
- Yokohama City University School of Medicine, Postgraduate School of Medicine, PhD
- 2001-2002
- National Jewish Health, Department of Medicine, Research Associate
Residency
- 1990-1992
- Tachikawa Sogo Hospital, Internal Medicine
- 1992-1993
- Ohji Seikyo Hospital, Respiratory Medicine
Fellowship
- 1993-1997
- Yokohama City University School of Medicine, Pulmonary and Critical Care Medicine
- 1998-2000
- Cleveland Clinic Foundation, Department of Pulmonary and Critical Care Medicine (Cleveland, OH), Postdoctoral Fellow
Special Interests
Research Interests
Mari Numata-Nakamura has 14 years of experience as a clinical pulmonologist and works in broad range of medicine. She currently focuses on research investigating the role of pulmonary surfactant in regulating innate immunity in the lung, with special emphasis upon surfactant lipid antagonism of inflammation and viral infection. She discovered the anti-viral properties of the surfactant lipid palmitoyl-oleoyl-phophatidylglycerol (POPG). The long term goals of her research are to bring basic research observations to treatment of patients.
Board Certification
2006: Allergy and Immunology
1998: Internal Medicine
1998: Pulmonary and Critical Care Medicine
Teaching or Professional Positions
Resident Training Programs:
Yokohama City University Hospital
Yokohama City University Medical Center
Kanagawa Cardiovascular and Respiratory Center
Summer student training at NJH
Professional Positions:
2012-Present: Assistant Professor, Department of Medicine, National Jewish Health
2009-2012: Instructor, Department of Medicine, National Jewish Health
2006-2009: Research Associate, Department of Medicine, National Jewish Medical and Research Center
2003-2006: Senior Chief physician, Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center
2002-2003: Assistant professor, Yokohama City University Medical Center, Critical Care and Medical Emergency Center
2000-2001: Chief physician, National Yokohama Hospital, Department of Respiratory Medicine
1997-1998: Staff, Yokohama City University School of Medicine, The Critical Care and Medical Emergency Center
Professional Memberships
American Thoracic Society
American Lung Association
Japanese Society of Internal Medicine
Japanese Respiratory Society
Japanese Society of Allergology
Japanese Society of Medical Oncology
Awards & Recognition
Academic Achievements:
Colorado Bioscience Discovery Evaluation Grant Program (CBDEG) 2009-2010 (PI: Voelker)
Suppression of Repiratory Syncytial Virus Infection by Pulmonary Surfactant Phospholipids. (Co-Investigator)
R01 HL094629 (PI: Voelker) (7/1/10-6/30/15) NIH/NHLBI (PI: Voelker)
Anionic Surfactant Lipid Regulation of Inflammation and Infection in the Lung (Co-Investigator)
Micro funding opportunity from the Basic Science Section 2010 in National Jewish Health. (PI: Numata-Nakamura)
Colorado Bioscience Discovery Evaluation Grant Program (CBDEG) 2012-2013
Novel Antiviral Lipids for Extended Prophylaxis and Post-Infection Treatment of Respiratory Syncytial Virus Infections (PI: Numata-Nakamura)
Honors:
2011:
I-CLIPP (The International Conference on Lung Innate Immunity and Pulmonology at ATS
The i-CLIPP 2011 Peter M Hansen Award for the Best Poster Presentation
2009:
American Thoracic Society Travel Award Grant
ATS Assembly on Microbiology, Tuberculosis and Pulmonary Infections
2009 International Conference, San Diego, California
2008:
American Thoracic Society Travel Award Grant
ATS Assembly on Microbiology, Tuberculosis and Pulmonary Infections
2008 International Conference, Toronto, Canada
Publications
Numata M, Kandasamy P, and Voelker DR. Pulmonary Surfactant Phosphatidylglycerol Acts a Novel Anti-Inflammatory and Anti-Viral Agents. 2012. Editorial Review by Expert Review of Respiratory Medicine (in press).
Numata M, Kandasamy P, Nagashima Y, Posey J, Hartshorn K, Woodland D and Voelker DR. Phosphatidylglycerol Suppresses Influenza A Virus Infection. Am J Respir Cell Mol Biol. 46:479–487, 2012.
Numata M, Chu HW, Dakhama Azzeddine, Voelker DR. “ The Pulmonary Surfactant Phospholipid, Phosphatidylglycerol, Inhibits Respiratory Syncytial Virus Induced Inflammation and Infection.Proc Natl Acad Sci USA. 2010. 107(1): 320-325
This article was selected as highlighted paper by PNAS in this issue and Cell. Viral treatment under our noses. Proc Natl Acad Sci USA. 2010. 107(1): 1-2. Leading edge. Molecular Medicine Select. Surfing new antivirals. Cell. 2010. 140:167-169.
Numata M, Voelker DR.: Asthma and Infections. (eds): Martin RJ, Rand Sutherland E. Lung Biology in Health and Disease. Volume 238:45-165. Chapter10: Pulmonary Surfactant. Innate Immunity and Asthma.
**Kuronuma K, Mitsuzawa H, Takeda K, Nishitani C, Chan ED, Kuroki Y, Nakamura M, and Voelker DR. “ Anionic Pulmonary Surfactant Phosphlipids Inhibits Inflammatory Responsed From Alveolar Macrophages and U937 Cells By Binding The Lipopolysaccharide Interacting Proteins CD14 and MD2. J Biol Chem. 2009. 264:25488-25500. **This article was selected as paper of the week by JBC.
