- Acute Lung Injury
- Cellular and Molecular Biology
- Cystic Fibrosis
- Gene Expression
- HIV/AIDS: Safety and Efficacy of Medications
- Infectious Diseases
- Mycobacterium Abscessus and Neutrophils
- Neutrophil Biology
- Type I Interferon Responses
- Viral Infections
Education & Training
- University of Colorado Denver, Department of Pharmacology, PhD
My research has focused on the signalling mechanisms of inflammatory and immune cells. Recently, my research is directed at the role of viral infections such as influenza to impact the pathogenisis of lung injury. Previous work has demonstrated the ability of a particular bacerial product, LPS, to drive the expression of specific anti-viral genes in neutrophils. The finding that neutrophils express anti-viral genes has instigated studies into the role of neutrophils in complications of respiratory viral infections. We use both cellular and animal models of viral infection and patients to assess the role of neutrophils in lung injury.
Fessler, M.B., Arndt, P.G., Just, I., Nick, J.A., Malcolm, K.C., Worthen, G.S. (2007) Dual role for RhoA in suppression and induction of cytokines in the human neutrophil. Blood 109, 1248-1256.
Malcolm K.C. and Worthen G.S. (2003) Lipopolysaccharide stimulates p38-dependent induction of anti-viral genes in neutrophils independently of paracrine factors. J. Biol. Chem. 278, 15693-15701.
Avdi, N.A., Malcolm, K.C., Nick, J.A., Worthen, G.S. (2002) p38 mitogen-activated protein kinase-mediated regulation of the c-jun NH2 terminal kinase pathway in human neutrophils: a role for PP2A. J. Biol. Chem. 277, 40687-40696.
Fessler M., Malcolm K.C., Duncan M., and Worthen G.S. (2002) An analysis of the lipopolysaccharide-stimulated human neutrophil using oligonucleotide microarrays and proteomics. J.Biol. Chem. 277, 31291-31302.
Malcolm, K.C., Ross, A.H., Qui, R.-G., Symons, M., and Exton, J.H. (1994) Activation of rat liver phospholipase D by the small GTP-binding protein RhoA. J. Biol. Chem. 269, 25951-25954