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Development of diagnostic methods to evaluate complement deficiencies, define genetic defects and study complement activation processes in vitro and in vivo. My laboratory specializes in clinical and diagnostic testing in the area of complement. We receive specimens from patients from all across the U.S., Canada and other countries, as well as participating in clinical and preclinical trials where complement activation is a potential contributor to the pathology of inflammation.

Teaching or Professional Positions

Director, Diagnostic Complement Laboratory, National Jewish Health
Director, Animal Serology Laboratory, National Jewish Health

Industry Relationships & Collaborations

National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.

Professional Memberships

AAI, CIS, ASM, International Complement Society (ICS), AAAAI, Assoc. Medical Laboratory Immunologists (AMLI)

Awards & Recognition

Section Editor (Complement), Manual of Clinical Laboratory Immunology, Editions 5, 6 and 7 (1997, 2002, 2005)

Publications

Thurman, JM, DM Kraus, G Girardi, D Hourcade, HJ Kang, LM Mitchell, PC Giclas, J Salmon, G Gilkeson, VM Holers. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice. Mol Immunol. 42(1):87-97, 2005.

Wen, L, JP Atkinson and PC Giclas. Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol. 113:585-93, 2004.

Park, JW, C Taube, A Joetham, K Takeda, T Kodama, A Dakhama, G McConville, CB Allen, G Sfyroera, LD Shultz, JD Lambris, P.C. Giclas, V.M. Holers, E.W. Gelfand. Complement Activation is Critical to Airway Hyperresponsiveness Following Acute Ozone Exposure”Am J Resp Crit Care Med. 169:726-732, 2004.

Kang, HJ, L Bao, Y Xu, R Quigg, PC Giclas and MV Holers. Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects. Clinical and Experimental Immunology. 136:194-199, 2004.