- Asthma Pharmacotherapy
- Biomarkers to predict treatment response
- Inhaled Corticosteroids
- Variability in treatments response
Programs & Services
- Division of Pediatric Clinical Pharmacology
- Pediatric Clinical Pharmacology Consult Service
Education & Training
- School of Medicine, SUNY at Buffalo, MD
- Children's Hospital of Buffalo, NY, Intern in Pediatrics
- Children's Hospital of Buffalo, NY, Resident in Pediatrics
- University of New York at Buffalo, Departments of Pharmacology and Therapeutics and Pediatrics, Clinical Pharmacology
My major research focus is on pharmacotherapy of childhood asthma and predicting response to asthma therapy.
I am the Principal Investigator for the Denver Site of the NHLBI AsthmaNet clinical research network. This multicenter collaborative network designs and conducts studies to address major issues of therapeutic intervention in childhood and adult asthma. Our site has lead a series of studies addressing significant clinical questions on the use of inhaled glucocorticoids in the treatment of asthma including patient phenotypes and genotypes associated with various degrees of response.
I am also a co-investigator for the Denver Site of the NIAID Inner City Asthma Consortium. I lead a protocol on the effect of therapeutic interventions to prevent asthma exacerbations that occur in the fall season. I am the Director of our center's site for a Colorado State Cardiovascular, Cancer and Pulmonary Disease Grant that focuses on asthma in the Denver Public School system. Our program is a combined epidemiology and case management program designed to help reduce school absence due to asthma.
Our research group also investigates asthma progression, early infant asthma and the management of severe childhood asthma.
Childhood asthma; Asthma pharmacotherapy; Inhaled corticosteroids; Biomarkers; Predictors of treatment response; Monitoring treatment response.
New York State Pharmacy Board
National Board of Medical Examiners
American Board of Pediatrics
Colorado State Board of Medical Examiners
American Board of Allergy and Immunology
Teaching or Professional Positions
Director of Clinical Pharmacology, Department of Pediatrics, National Jewish Health
Professor of Pediatrics and Pharmacology, University of Colorado Denver
Director of Pediatric Clinical Trials Center, Department of Pediatrics, National Jewish Health
Helen Wohlberg & Herman Lambert Chair in Pharmacokinetics, National Jewish Health
Co-Director of the Weinberg Clinical research unit and Director of the Clinical Research Unit/Pediatrics Section, National Jewish Health
Industry Relationships & Collaborations
National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.
Affiliations with the University of Colorado Denver
Professor of Pediatrics and Pharmacology
American Academy of Pediatrics
American Academy of Allergy Asthma and Immunology
Society of Pediatric Research
American Society of Pharmacology and Experimental Therapeutics
Colorado Allergy Society
American College of Allergy, Asthma and Immunology
American Thoracic Society
Colorado Trudeau Society/Medical Section of the American Lung Association of Colorado
Awards & Recognition
Helen Wohlberg & Herman Lambert Chair in Pharmacokinetics NHLBI/National Asthma Education and Prevention Program, Science Base Committee and Expert Panel
2001-Present: NHLBI/National Asthma Education and Prevention program, Expert Panel Advisory Board for update of asthma management in pregnancy guidelines.
2003-2004: Deputy Editor, Journal of Allergy and Clinical Immunology
Szefler SJ. Advances in Pediatric Asthma in 2011: Moving forward. J Allergy Clin Immunol 2012; 129:60-68. PMC 3032272; NIHMS 256545.
Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, Kita H, Liu AH, Penettieri RA, Schleimer RP, Minnicozzi M. Asthma outcomes: biomarkers. J Allergy Clin Immunol 2012;129;S9-23.
Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleeker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA. Comparison of Physician-Based, Biomarker-Based, and Symptom-Based Strategies for Adjustment of Inhaled Corticosteroid Therapy in Adults with Asthma: The Basalt Randomized Trial. JAMA, 2012;308:987-997.
Chipps BE. Zeoger RS, Borish L, Wenzel SE, Yegin A, Hayden ML, Miller DP, Bleecker ER, Simons FER, Szefler SJ, Weiss ST, Hasselkorn T. Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol, 2012;130:332-42.
Zeiger RS, Mauger D, Bacharier LB, Guilbert TW, Martinez FD, Lemanske RF, Strunk RC, Covar R, Szefler SJ, Boehmer S, Jackson DJ, Sorkness CA, Gern JE, Kelly HW, Friedman NJ, Mellon MH, Schatz M, Morgan WJ, Chinchilli VM, Raissy HH, Bade E, Malka-Rais J, Beigelman A, Taussig LM for the Childhood Asthma Research and Education Network of the National Heart, Lung and Blood Institute. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med 2011;365:1990-2001.