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Azzeddine Dakhama, PhD

Associate Professor
Department of Pediatrics

Profile
Office Information

Profile

Research Areas

Allergy
Asthma
Infectious Diseases
Inflammation

Gender:: Male

Education & Training

Education

1980: University of Rabat (Morocco), BS, Biology
1983: University of Lille (France), MS, Biology
1991: Laval University (Quebec, Canada), PhD, Biology

Fellowship

1992-1993: Laval University, Laval Hospital, Pulmonary Research Center (Quebec, Canada), Asthma, Hypersensitivity Pneumonitis, Lung Inflammation
1993-1996: University of British Columbia, St. Paul’s Hospital, Pulmonary Research Laboratory (Vancouver, Canada), Asthma, Respiratory Viral Infections, Lung Pathology

Special Interests

Research Interests

My research is focused on the mechanisms that determine the outcome of early age exposure to respiratory viral infection and allergen exposure. I am particularly interested in defining how maternal immunity and other factors (e.g. environmental pollution) influence the early host response to respiratory viruses and allergens in the postnatal development period.

Affiliations with the University of Colorado Denver

Associate Professor, Department of Pediatrics

Professional Memberships

American Thoracic Society (ATS)
American Academy of Allergy Asthma and Immunology (AAAAI)

Publications

Dakhama A, Lee YM, Ohnishi H, Jing X, Balhorn A, Takeda K, Gelfand EW. Virus-specific IgE enhances airway responsiveness on reinfection with respiratory syncytial virus in newborn mice. J Allergy Clin Immunol 2009; 123: 138-145.

Lee YM, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A. IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus. Am J Respir Crit Care Med. 2008; 177(2):208-218.

Dakhama A, Park JW, Taube C, Joetham A, Balhorn A, Miyahara N, Takeda K, Gelfand EW. The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus is critically dependent on the age at first infection and IL-13 production. J Immunol. 2005; 175:1876-1883.

Dakhama A, Park JW, Taube C, El Gazzar M, Kodama T, Miyahara N, Takeda K, Kanehiro A, Balhorn A, Joetham A, Loader JE, Larsen GL, Gelfand EW. Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2005; 288:L761-770.

Dakhama A, Park JW, Taube C, Chayama K, Balhorn A, Joetham A, Wei XD, Fan RH, Swasey C, Miyahara N, Kodama T, Alvarez A, Takeda K, Gelfand EW. The role of virus-specific immunoglobulin E in airway hyperresponsiveness. Am J Respir Crit Care Med. 2004; 170:952-9.