Scott Alper
PhD
- Integrated Department of Immunology
- Phone
- 303-270-2659
- Email
- alpers@njhealth.org
- Website Address
- University of Colorado Site
- Gender
- Male
Specialties
Research
Basic Immunology, Inflammation, Innate Immunity, Molecular Genetics
Affiliation with University of Colorado Denver
Assistant Professor in the Integrated Department of Immunology
Research Interests
Diseases of the immune system such as sepsis, asthma, and atherosclerosis affect millions of people worldwide, and the incidence of many of these diseases is rising. My lab is focused on understanding the regulation of the innate immune response, particularly as it relates to the basis for such immunological diseases. We are using a comparative genomics approach in the nematode C. elegans and mammalian cell culture to identify novel regulators of the innate immune response.
Education & Training
Education
- Harvard University
- PhD, 1996
Recent or Important Publications
Alper, S., McElwee, M., Apfeld, J., Lackford, B., Freedman, J.H., and Schwartz, D.A. Germline Proliferation regulates distinct signaling pathways in C. elegans to control lifespan and innate immunity. Submitted (2009).
Yang, I.V., Alper, S., Lackford, B., Rutledge, H., Burch, L.H., and Schwartz, D.A. Identification of Hedgehog signaling and novel transcription factors involved in the regulation of the systemic response to LPS. Submitted (2009).
Alper, S., Laws, R., Lackford, B., Boyd, W.A., Dunlap, P., Freedman J.H., and Schwartz, D.A.. Identification of Novel Innate Immunity Genes and Pathways Using a Comparative Genomics Approach. Proc. Natl. Acad. Sci. USA. 105: 7016-7021. (2008).
Alper, S., McBride, S., Lackford, B., Freedman, J.H., and Schwartz, D.A.. Specificity and Complexity of the C. elegans Innate Immune Respone. Mol. Cell. Biol. 27: 5544-5553 (2007).
