Ivana V Yang
PhD
- Department of Medicine
- Assistant Professor
- Phone
- 303-270-2589
- Fax
- 303-270-2136
- Email
- yangi@njhealth.org
- Gender
- Female
Specialties
Research
Basic Immunology, Cellular and Molecular Biology, Infectious Diseases, Inflammation
Teaching & Professional Positions
2008-Present: Assistant Professor, Department of Medicine, National Jewish Health
2005–2008: Staff Scientist, Laboratory of Environmental Lung Disease, National Institute of Environmental Health Sciences (NIEHS) and National Heart Lung and Blood Institute (NHLBI)
2003–2005: Assistant Research Professor, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center
Research Interests
My responsibilities are divided equally between primary research and the development of the Center for Genetics and Therapeutics.
My research centers on identification of novel innate immune genes by using genetic mapping and expression studies in mice and cultured macrophages stimulated with bacterial, viral, and fungal PAMPs (TLR ligands). Novel genes identified using these approaches are tested functionally by RNA interference in macrophages and in mouse lines with targeted mutations. Polymorphisms in human orthologs of candidate genes are then tested in patient cohorts.
My main responsibility within the Center for Genetics and Therapeutics is to establish technologies to enable genetics and genomics research at National Jewish Health. This includes establishing capabilities for high-throughput sequencing, expression profiling, genotyping, and genome-wide studies of DNA methylation and histone modifications.
Education & Training
Education
- University of North Carolina at Chapel Hill
- PhD, 2000
Fellowships
- The Institute for Genomic Research
- Functional Genomics, 2001-2003
Awards & Recognition
2003: EU-US Workshop on Molecular Signatures of DNA Damage Induced Stress Response Young Scientist Travel Award
2002: Aspen Cancer Conference Young Investigator
1996: Phi Beta Kappa
Recent or Important Publications
Brass D.M.*, Yang I.V.*, Kennedy M.P., Whitehead G.S., Rutledge H., Burch L.H., Schwartz D.A. LPS-induced airway remodeling is a fibroproliferative process. Immunogenetics. In press.
Yang, I.V., Burch, L.H., Steele, M.P., Savov, J.D., Hollingsworth, J.W., Berman, K.G., Speer, M.C., Brown, K.K., Schwarz, M.I., Schwartz, D.A. Gene expression profiling of familial and sporadic interstitial pneumonia. Am. J. Resp. Crit. Care Med. 175, 45-54 (2007) (with accompanying editorial).
Burch, L.H., Yang, I.V., Whitehead, G.S., Berman, K.G., Chao, F.G., Schwartz, D.A. Transcriptional response to endotoxin reveals role for interferon gamma in lung neutrophil recruitment. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L677-82 (2006).
Bloom, G.*, Yang, I.V.*, Boulware, D., Kwong, K.Y., Coppola, D., Eschrich, S., Quackenbush, J., Yeatman, T.J. Multi-platform, multi-site, microarray-based human tumor classification. Am. J. Pathol. 164, 9-16 (2004).
Yang, I.V., Chen, E., Hasseman, J.P., Liang, W., Frank, B.C., Wang, S., Sharov, V., Saeed, A.I., White, J., Li, J., Lee, N.H., Yeatman, T.J., Quackenbush, J. Within the fold: assessing differential expression measures and reproducibility of microarray assays. Genome Biol. 3, research0062 (2002).
Curriculum Vitae
View Curriculum Vitae
