Stijn P De Langhe
PhD
- Department of Pediatrics
- Assistant Professor
- Phone
- 303-398-1763
- Email
- delanghes@njhealth.org
- Gender
- Male
Specialties
Research
Asthma, Cellular and Molecular Biology, COPD/Chronic Obstructive Pulmonary Disease/Emphysema, Other Pulmonary Disease Research
Affiliation with University of Colorado Denver
Assistant Professor, Department of Cell and Developmental Biology
Program in Cell Biology, Stem Cells and Developmental Biology
Research Interests
Our group focuses on lung development, lung regeneration and lung stem cells. We are especially interested in how Wnt and FGF signaling pathways control the differentiation, proliferation and maintenance of several mesenchymally derived cell lineages, in particular the parabronchial smooth muscle cells. For our research, we make extensive use of transgenic and knock out mice.
Education & Training
Education
- Ghent University (Belgium)/Childrens Hospital Los Angeles
- PhD, Biotechnology, 2005
- Ghent University (Belgium)
- MS, Biotechnology/Biochemistry, 1998
Fellowships
- Childrens Hospital Los Angeles/USC Keck School of Medicine
- 2005-2007
Recent or Important Publications
De Langhe, S.P., Carraro, G., Tefft, D., Li, C., Xu, X., Chai, Y., Minoo, P., Hajihosseini, M.K., Drouin, J., Kaartinen, V., et al. (2008). Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE 3, e1516.
De Langhe, S.P., Carraro, G., Warburton, D., Hajihosseini, M. K., and Bellusci, S. (2006). Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299, 52-62.
del Moral,P.M., De Langhe,S.P., Sala,F.G., Veltmaat,J.M., Tefft,D., Wang,K., Warburton,D., and Bellusci,S. (2006). Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev. Biol. 293, 77-89.
Mailleux,A.A., Kelly,R., Veltmaat,J.M., De Langhe,S.P., Zaffran,S., Thiery,J.P., and Bellusci,S. (2005). Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132, 2157-2166.
De Langhe,S.P., Sala,F.G., del Moral,P.M., Fairbanks,T.J., Yamada,K.M., Warburton,D., Burns,R.C., and Bellusci,S. (2005). Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev. Biol. 277, 316-331.
