Gregory P Downey
MD, FRCP
- Department of Medicine
- Executive Vice President, Academic Affairs
- Professor
- Phone
- 303-398-1436
- Fax
- 303-270-2243
- Gender
- Male
Specialties
Adults
Asthma
Allergic Asthma, Allergic Bronchopulmonary Aspergillosis, Exercise-Induced Asthma, Non-Allergic Asthma
Autoimmune Diseases and Rheumatoid Conditions
Primary & Secondary Immune Deficiencies
COPD/Chronic Obstructive Pulmonary Disease
Alpha-1 Antitrypsin Deficiency, Chronic Bronchitis, Chronic Cough, Emphysema
Mycobacterial (TB/nontuberculous) and Respiratory Infections
Bronchiectasis, Fungal Lung Disease, Immune Deficiencies, Infectious Diseases (Chronic Respiratory Infections), Nontuberculous Mycobacterial Infections
Occupational and Environmental Health Sciences
Asbestosis, Hypersensitivity Pneumonitis, Sarcoidosis
Pulmonary/Lung Conditions
Allergies, Autoimmune Lung Diseases, Interstitial and Fibrotic Lung Disease, Lymphangioleiomyomatosis (LAM), Respiratory Infections
Research
Basic Immunology, Cellular and Molecular Biology, Infectious Diseases, Inflammation
Teaching & Professional Positions
2007-Present:
Professor, Dept of Pediatrics, National Jewish Health
2007-Present: Professor, Integrated Department of Immunology, National Jewish Health & University of Colorado Denver
2006-Present: Executive Vice President for Academic Affairs and Professor, Dept of Medicine, National Jewish Health
2004-2006: Vice-Chair, Dept of Medicine, University of Toronto
2001-2006: Canada Research Chair in Respiration, Canadian Institutes of Health Research
2001-2006: Associate Director, Institute of Medical Sciences, University of Toronto 8/01-10/30/06
2000-2006: Director, Division of Respirology, University of Toronto
1999-2006: Professor, Dept of Medicine, University of Toronto
1999-2005: R. Fraser Elliot Chair in Transplantation Research, Toronto General Hospital, The University Health Network
1995-2000: Training Program Director, Division of Respirology, University of Toronto
1993-2006: Full Member, School of Graduate Studies, University of Toronto
1993-1999: Associate Professor, Dept of Medicine, University of Toronto
1989-1993: Associate Member, School of Graduate Studies, University of Toronto
1988-1993: Assistant Professor, Dept of Medicine, University of Toronto
1987-1988: Assistant Professor, Dept of Medicine, University of Colorado Denver
Professional Memberships/Societies
Royal College of Physicians and Surgeons of Canada, Full Member
American Thoracic Society, Full Member; Member Program Committee for Assembly on Allergy, Immunology, and Inflammation, 1996-Present
American College of Chest Physicians, Full Member
Member of Forum on Critical Care
American Society for Cell Biology, Full Member.
Scientific Forum on Lung Cell and Molecular Biology
American Association for the Advancement of Science, Full Member
Ontario Thoracic Society, Full Member
Federation of American Societies for Experimental Biology, Full Member
Clinical Research Society or Toronto, President, 1996-1999
Publications by This Author
Link to Faculty Publications
Link to PubMed for more papers
Board Certified
National Board of Medical Examiners, Parts 1, 2 and 3
American Board of Internal Medicine
Fellow of the Royal College of Physicians and Surgeons of Canada
Royal College of Physicians and Surgeons of Canada: Special Certificate in Respiratory Diseases
American Board of Pulmonary Diseases
Special Certification in Critical Care (American Board of Internal Medicine)
Fellow of the American College of Chest Physicians
Service
Education & Training
Education
- University of Manitoba (Winnipeg, Canada)
- MD, 1980
Residencies
- Beth Israel Hospital, Harvard Medical School
- Residency in Internal Medicine, 1981-1983
- Beth Israel Hospital, Harvard Medical School
- Internship in Internal Medicine, 1980-1981
Fellowships
- National Jewish Health and University of Colorado Denver
- Research Fellowship in Pulmonary Cell Biology, 1985-1988
- University of Colorado Denver
- Clinical Fellowship in Pulmonary Medicine, 1984-1986
Awards & Recognition
2002-Present: Assoc. Editor, American Journal of Respiratory Cell and Molecular Biology
2006: Canadian Cystic Fibrosis Foundation Zeller’s Senior Scientist Award for outstanding contributions to CF Research
2004: Scholar, McLaughlin Centre for Molecular Medicine, U. of Toronto
2001: Tier 1 Canada Research Chair in Respiration, Canadian Institutes of Health Research
1999: R. Fraser Elliott Chair in Transplantation Research, Toronto General Hospital, University Health Network
1999: Dept. of Med. Research Award, U. of Toronto
1997: Elected to the American Society for Clinical Investigation. Recipient of the William Goldie Prize, Dept. of Med., U. of Toronto for a contribution of notable merit to the advancement of knowledge in Internal Medicine
1996: Institute of Medical Science, Dept. of Medicine, U. of Toronto. Special Recognition for Supervision of Graduate Students who have made a notable scientific contribution
1992: Royal College of Physicians and Surgeons of Canada, Canadian Society of Clinical Investigation Joe Doupe Young Investigator’s Award
1989: Career Scientist Award, Ontario Ministry of Health
Recent or Important Publications
Suzuki T, Yamashita C, Zemans RL, Briones, N, Van Linden A, Downey GP. Leukocyte elastase induces lung epithelial apoptosis via a PAR-1, NF(Kappa)B, and p53-dependent pathway. Am J Respir Cell Mol Biol, Epub ahead of print March 23, 2009.
Herrera Abreu MT, Penton PC, Kwok V, Vachon E, Shalloway D, Vidali L, Lee W, McCulloch CA, Downey GP. Tyrosine phosphatase PTP(Alpha) regulates focal adhesion remodeling through Rac1 activation. Am J Physiol (Cell Physiol). 294(4):C931-944, 2008.
Vachon E, Martin R, Kwok V, Cherepanov V, Chow CW, Doerschuk CM, Plumb J, Grinstein S, Downey GP. CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood 110:4492-4502, 2007.
Wang Y, Vachon E, Jinyi Zhang J, Cherepanov v, Li J, Saito K, Moraes T, Suzuki T, Kruger J, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Siminovitch KA, Mustelin T, Downey GP. Tyrosine phosphatase MEG2 is required for neural tube formation, bone development, platelet, and lymphocyte function in mice. J Exp Med 202:1587-1597, 2005.
Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T. Control of vesicle fusion by a tyrosine phosphatase MEG2. Nature Cell Biol 6:831-839, 2004.
