Hugo R Rosen
MD
- Integrated Department of Immunology
- Phone
- 303-315-2537
- Fax
- 303-315-5711
- Email
- Hugo.rosen@UCHSC.edu
- Gender
- Male
Specialties
Adults
Gastroenterology
GERD, Motility Disease, Peptic Ulcer Disease
Research
Infectious Diseases
Professional Memberships/Societies
AAI, AST, AASLD
Publications by This Author
Link to Faculty Publications
Board Certified
Internal Medicine
Gastroenterology
Research Interests
Gastroenterology / Hepatology / Liver Transplantation.
Our laboratory is interested in the immune response to hepatitis C virus (HCV), particularly understanding the mechanisms associated with spontaneous or therapeutic-induced clearance versus viral persistence. Although the focus of our lab has been primarily on the role of antigen-specific T cells, we are also characterizing the potential role of innate immunity (e.g., dendritic and natural killer cells). The central theme of our studies is to define why HCV causes diverse outcomes in exposed individuals and characterize the division of labor, i.e., role played by different components of the immune system.
The theme of our center grant is to understand mechanisms of immune evasion in HCV infection. Dr. Rosen is the Program Director; Dr. Young Hahn (University of Virginia) and Dr. Stephen Polyak (University of Washington) are the co-investigators. The specific aims include:
1. To examine the innate arm of the immune system to determine which of their effector functions are the most critical for control of HCV infection.
2. To define how professional antigen presenting cells (APC) influence the ability of NK and T cells to mediate viral clearance.
3. To understand how the HCV core protein within or outside the cell regulates innate signaling pathways such as IRF, Stat-JAK, and iNOS. Does viral sequence and structural variation contribute to differential signaling?
4. To elucidate the underlying mechanisms of regulatory T cell development (e.g., antigen presentation by immature DCs, core/gC1qR engagement) and their role in establishing persistence.
Education & Training
Education
- University of Miami, Florida
- MD, 1985-1989
Residencies
- Beth Israel-Deaconess Hospital, Harvard Medical School (Boston, MA)
- Internal Medicine, 1990-1992
Fellowships
- University of California, Los Angeles; UCLA Center for Health Sciences
- Integrated Program in Gastroenterology and Hepatology, 1992-1995
Awards & Recognition
Associate Editor, Liver Transplantation
Board of Directors, American Society of Transplantation
Recent or Important Publications
Golden-Mason L, Rosen HR. Natural killer cells: Primary target for hepatitis C virus immune evasion strategies? Liver Transpl. 2006 Mar;12(3):363-72.
Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, Tavis JE, Rosen HR. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med. 2005 Jun 6;201(11):1725-31 (see comments).
Rosen HR, Hinrichs DJ, Leistikow RL, Calendar G, Nishimura M, Lewinsohn. Selection of HCV-specific CD8+ T cells by donor HLA alleles following liver transplantation. J Immunology Cutting Edge 2004 Nov 1;173(9):5355-9.
Wertheimer AW, Bakke A, Rosen HR. Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease; Hepatology; 2004: 40: 335-345.
Simon B, Cornell K, Clark T, Chou S, Rosen HR, Barry R. DNA vaccination protect mice against challenge with recombinant Listeria monocytogenes expressing hepatitis C virus NS3 protein. Infect Immun. 2003 Nov; 71(11): 6372-80.
