Patricia Creveling Giclas
PhD
- Department of Pediatrics
- Professor
- Phone
- 303-398-1217
- Fax
- 303-270-2128
- Email
- giclasp@njhealth.org
- Gender
- Female
Teaching & Professional Positions
Director, Diagnostic Complement Laboratory, National Jewish Health
Director, Animal Serology Laboratory, National Jewish Health
Professional Memberships/Societies
AAI, CIS, ASM, International Complement Society (ICS), AAAAI, Assoc. Medical Laboratory Immunologists (AMLI)
Publications by This Author
Link to Faculty Publications
Link to PubMed for more papers
Research Interests
Development of diagnostic methods to evaluate complement deficiencies, define genetic defects and study complement activation processes in vitro and in vivo.
My laboratory specializes in clinical and diagnostic testing in the area of complement. We receive specimens from patients from all across the U.S., Canada and other countries, as well as participating in clinical and preclinical trials where complement activation is a potential contributor to the pathology of inflammation.
Service
Education & Training
Education
- University of Arizona
- PhD, Molecular Biology, 1976
Fellowships
- National Jewish Health
- Immunopathology, 1979
- Scripps Clinic and Research Foundation (La Jolla, CA)
- Immunopathology, 1977
Awards & Recognition
Section Editor (Complement), Manual of Clinical Laboratory Immunology, Editions 5, 6 and 7 (1997, 2002, 2005)
Recent or Important Publications
Thurman, JM, DM Kraus, G Girardi, D Hourcade, HJ Kang, LM Mitchell, PC Giclas, J Salmon, G Gilkeson, VM Holers. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice. Mol Immunol. 42(1):87-97, 2005.
Wen, L, JP Atkinson and PC Giclas. Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol. 113:585-93, 2004.
Park, JW, C Taube, A Joetham, K Takeda, T Kodama, A Dakhama, G McConville, CB Allen, G Sfyroera, LD Shultz, JD Lambris, P.C. Giclas, V.M. Holers, E.W. Gelfand. Complement Activation is Critical to Airway Hyperresponsiveness Following Acute Ozone Exposure”Am J Resp Crit Care Med. 169:726-732, 2004.
Kang, HJ, L Bao, Y Xu, R Quigg, PC Giclas and MV Holers. Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects. Clinical and Experimental Immunology. 136:194-199, 2004.
