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Stanley J Szefler
MD
- Department of Pediatrics
- Head, Pediatric Clinical Pharmacology
- Helen Wohlberg & Herman Lambert Chair in Pharmacokinetics
- Co-Director, Weinberg Clinical Research Unit
- Director, Pediatric Clinical Trials Center
- Professor
- Phone
- 303-398-1876
- Fax
- 303-270-2189
- Email
- szeflers@njhealth.org
- Gender
- Male
Specialties
Pediatrics
Asthma
Allergic Asthma, Exercise-Induced Asthma, Non-Allergic Asthma
Pharmacology
Immunomodulator Therapy, Steroid Adverse Effects, Steroid Pharmacokinetics, Steroid Sensitivity and Resistance
Affiliation with University of Colorado Denver
Professor of Pediatrics and Pharmacology
Teaching & Professional Positions
Director of Clinical Pharmacology, Department of Pediatrics, National Jewish Health
Professor of Pediatrics and Pharmacology, University of Colorado Denver
Director of Pediatric Clinical Trials Center, Department of Pediatrics, National Jewish Health
Helen Wohlberg & Herman Lambert Chair in Pharmacokinetics, National Jewish Health
Co-Director of the Weinberg Clinical research unit and Director of the Clinical Research Unit/Pediatrics Section, National Jewish Health
Professional Memberships/Societies
American Academy of Pediatrics
American Academy of Allergy Asthma and Immunology
Society of Pediatric Research
American Society of Pharmacology and Experimental Therapeutics
Colorado Allergy Society
American College of Allergy, Asthma and Immunology
American Thoracic Society
Colorado Trudeau Society/Medical Section of the American Lung Association of Colorado
Publications by This Author
Link to Faculty Publications
Link to PubMed for more papers
Clinical Interests
Childhood asthma; Asthma pharmacotherapy; Inhaled corticosteroids; Biomarkers; Predictors of treatment response; Monitoring treatment response
Board Certified
New York State Pharmacy Board
National Board of Medical Examiners
American Board of Pediatrics
Colorado State Board of Medical Examiners
American Board of Allergy and Immunology
Research Interests
My major research focus is on pharmacotherapy of childhood asthma and predicting response to asthma therapy.
I am the Principal Investigator for the Denver Site of the NHLBI Childhood Asthma Management Program Continuation Study that is a long term study on the effect of therapeutic intervention with anti-inflammatory therapy. I am also the Principal Investigator for the Denver Site of the NHLBI Childhood Asthma Research and Education Network. This multicenter collaborative network designs and conducts studies to address major issues of therapeutic intervention in childhood asthma.
I am a Co-Investigator for the Denver Site of the NHLBI Asthma Clinical Research Network. Our site has lead a series of studies addressing significant clinical questions on the use of inhaled glucocorticoids in the treatment of asthma including patient phenotypes and genotypes associated with various degrees of response.
I am also a co-investigator for the Denver Site of the NIAID Inner City Asthma Consortium. I serve as the chair of the Protocol Development Committee and lead a protocol on the effect of biomarker-guided asthma therapy. I am the Director of our center's site for a Colorado State Cardiovascular, Cancer and Pulmonary Disease Grant that focuses on asthma in the Denver Public School system. Our program is a combined epidemiology and outreach program designed to help reduce school absence due to asthma.
Our research group is currently organizing efforts to investigate asthma progression, early infant asthma and the management of severe childhood asthma.
Service
Education & Training
Education
- School of Medicine, SUNY at Buffalo
- MD, 1971-1975
Residencies
- Children's Hospital of Buffalo, NY
- Resident in Pediatrics, 1976-1977
- Children's Hospital of Buffalo, NY
- Intern in Pediatrics, 1975-1976
Fellowships
- University of New York at Buffalo, Departments of Pharmacology and Therapeutics and Pediatrics
- Clinical Pharmacology, 1977-1979
Awards & Recognition
Helen Wohlberg & Herman Lambert Chair in Pharmacokinetics NHLBI/National Asthma Education and Prevention Program, Science Base Committee and Expert Panel
2001-Present: NHLBI/National Asthma Education and Prevention program, Expert Panel Advisory Board for update of asthma management in pregnancy guidelines.
2003-2004: Deputy Editor, Journal of Allergy and Clinical Immunology
Recent or Important Publications
Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman S, Israel E for the National Heart, Lung and Blood Institute’s Asthma Clinical Research Network. Effect of Beta 2-adrenergic receptor polymorphism on response to long-acting beta 2 agonist in asthma (LARGE trial): a genotype-stratified, randomized, placebo-controlled, crossover trial. Lancet 2009;374:1754-64.
Larsen GL, Morgan W, Heldt GP, Mauger DT, Boehmer SJ, Chinchilli VM, Lemanske RF, Martinez F, Strunk RC, Szefler SJ, Zeiger RS, Taussig LM, Bacharier LB, Guilbert TW, Redford S, Sorkness CA for the Childhood Asthma Research and education Network of the National Heart, Lung and Blood Institute. Impulse oscillometry versus spirometery in a long-term study of controller therapy for pediatric asthma. J Allergy Clin Immunol, 2009; 123:861-7.
Strunk RC, Sternberg AL, Szefler SJ, Zeiger RS, Bender BG, Tonascia J on behalf of the Childhood Asthma Management Program (CAMP) Research Group. Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. J Pediatr 2009; 154:682-687.
Covar RA, Szefler SJ, Zeiger RS, Sorkness CA, Moss M, Mauger DT, Boehmer SJ, Strunk, RC, Martinez FD, Taussig LM for the Childhood Asthma Research and Education Network. Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children. J Allergy Clin Immunol 2008; 122:697-699.
Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O’Connor GT, Morgan WJ, Katan M, Pongracic JA, Teach SJ, Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu AH, Wildfire JJ, Curry MD, Busse WW. Adding exhaled nitric oxide to guideline-based asthma treatment in inner-city adolescents and young adults: a randomized controlled trial. Lancet 2008, 372:1065-1072.
