Phone

303-270-2078

Fax

303-270-2325

Email

perrauda@njhealth.org

Website Address

University Profile

Gender

Female

Research Interests

Ion homeostasis regulation in immune cells.

Education & Training

Education

Kansai Medical University (Osaka, Japan), Dept. of Molecular Genetics

Guest scientist in Prof. Tomohiro Kurosaki''s research, 1998-1999

University of Würzburg, Germany

PhD, 1998

University of Marburg, Germany

MS (Diplom), 1994

University of Bonn, Germany

BA (Vordiplom), 1991

Fellowships

Harvard Medical School / Beth-Israel Hospital, Dept. of Pathology

Post-Doctoral Fellow, 1998-2000

University of Washington, Dept. of Pediatrics and Immunology

Senior Post-Doctoral Fellow, 2000-2002

Recent or Important Publications

Perraud A.-L., Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM.: Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels, J Biol Chem 280: 6138-6148, 2005.

Schmitz C. *, Perraud A.-L. *, Johnson C. O., Inabe K., Smith M. K., Penner R., Kurosaki T., Fleig A., Scharenberg A. M.: Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7, Cell 114(2):191-200, 2003.

Perraud A.-L., Shen B., Dunn C. A., Rippe K., Smith M. K., Bessman M. J., Stoddard B. L., Scharenberg, A. M.: NUDT9, a member of the nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase, J Biol Chem 278(3):1794-801, 2003.

Launay P. *, Fleig A. *, Perraud A.-L., Scharenberg, A. M., Penner R., Kinet J.-P.: TRPM4 Is a Ca(2+)-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization, Cell 109(3): 397-407, 2002.

Perraud A.-L.*, Fleig A.*, Dunn C. A.*, Bagley L. A., Launay P., Schmitz C., Stokes A., Zhu Q., Bessman M. J., Penner R., Kinet J.-P., and Scharenberg A. M.: ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology, Nature 411(6837): 595-599, 2001.