Joseph J Lucas
PhD
- Department of Pediatrics
- Associate Professor
- Phone
- 303-398-1206
- Fax
- 303-270-3182
- Email
- lucasj@njhealth.org
- Gender
- Male
Specialties
Research
Allergy, Asthma, Basic Immunology, Cancer, Cellular and Molecular Biology, Infectious Diseases, Inflammation
Publications by This Author
Link to Faculty Publications
Research Interests
Cell cycle control in normal and cancer cells. Signal transduction in mast cells and T lymphocytes.
My major research interest is the role of G1-phase cyclin-dependent kinases and their associated proteins and substrates in cell cycle control in normal and transformed cells. These complexes of molecules are important as components of them are deficient in many tumors derived from T and B-lymphocytes and from breast epithelial cells. I am also involved in studies designed to delineate the signal transduction pathways which lead to effector functions in T lymphocytes and in mast cells. Elucidation of these pathways is important in understanding a variety of immunological disorders.
Education & Training
Education
- University of Pennsylvania (Philadelphia, PA)
- PhD, Biochemistry/Virology, 1972
- LaSalle College (Philadelphia, PA)
- BA, Chemistry, 1967
Fellowships
- Department of Microbiology, SUNY at Stony Brook
- Postdoctoral Fellow with Joseph R. Kates, PhD, 1973-1976
- Department of Chemistry, University of Colorado (Boulder, CO)
- Postdoctoral Fellow with Joseph R. Kates, PhD, 1972-1973
Awards & Recognition
Recipient of Damon Runyon Memorial Fund Fellowship
Recipient of NIH Fellowship
Recent or Important Publications
Zhang, F., Nielsen, L. D., LUCAS, J. J. and Mason, R. J. “TGF-? antagonizes alveolar type II proliferation induced by KGF.” Amer. J. Respir. Cell Mol. Biol. 31:679-686(2004)
Li, G., Domenico, J., LUCAS, J. J. and Gelfand, E. W. “Identification of multiple cell cycle regulatory functions of p57Kip2 in human T lymphocytes.” J. Immunol. 173:2383-2391(2004).
LUCAS, J. J., Domenico, J. and Gelfand, E. W. “Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.” Molec. Cancer Res. 2:105-114(2004).
Wei, X., Sun, W., Fan, R., Hahn, J., Joetham, A., Li, G., Webb, S., Garrington, T., Dakhama, A., LUCAS, J. J., Johnson, G. L. and Gelfand, E. W. “MEF2C regulates c-Jun but not TNF-? gene expression in stimulated mast cells.” Eur. J. Immunol. 33:2903-2909(2003).
Nagasawa, M., Gelfand, E. W. and LUCAS, J. J. “Accumulation of high levels of the p53 and p130 growth-suppressing proteins in cell lines stably over-expressing cyclin-dependent kinase 6(cdk6).” Oncogene. 20:2889-2899(2001).
