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Azzeddine Dakhama
PhD
- Department of Pediatrics
- Associate Professor
- Phone
- 303-398-1705
- Gender
- Male
Specialties
Research
Asthma, Allergy, Infectious Disease, Inflammation
Affiliation with University of Colorado Denver
Associate Professor, Department of Pediatrics
Professional Memberships/Societies
American Thoracic Society (ATS)
American Academy of Allergy Asthma and Immunology (AAAAI)
Publications by This Author
Link to Faculty Publications
Link to PubMed for more papers
Research Interests
My research is focused on the mechanisms that determine the outcome of early age exposure to respiratory viral infection and allergen exposure. I am particularly interested in defining how maternal immunity and other factors (e.g. environmental pollution) influence the early host response to respiratory viruses and allergens in the postnatal development period.
Education & Training
Education
- Laval University (Quebec, Canada)
- PhD, Biology, 1991
- University of Lille (France)
- MS, Biology, 1983
- University of Rabat (Morocco)
- BS, Biology, 1980
Fellowships
- University of British Columbia, St. Paul’s Hospital, Pulmonary Research Laboratory (Vancouver, Canada)
- Asthma, Respiratory Viral Infections, Lung Pathology, 1993-1996
- Laval University, Laval Hospital, Pulmonary Research Center (Quebec, Canada)
- Asthma, Hypersensitivity Pneumonitis, Lung Inflammation, 1992-1993
Recent or Important Publications
Dakhama A, Lee YM, Ohnishi H, Jing X, Balhorn A, Takeda K, Gelfand EW. Virus-specific IgE enhances airway responsiveness on reinfection with respiratory syncytial virus in newborn mice. J Allergy Clin Immunol 2009; 123: 138-145.
Lee YM, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A. IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus. Am J Respir Crit Care Med. 2008; 177(2):208-218.
Dakhama A, Park JW, Taube C, Joetham A, Balhorn A, Miyahara N, Takeda K, Gelfand EW. The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus is critically dependent on the age at first infection and IL-13 production. J Immunol. 2005; 175:1876-1883.
Dakhama A, Park JW, Taube C, El Gazzar M, Kodama T, Miyahara N, Takeda K, Kanehiro A, Balhorn A, Joetham A, Loader JE, Larsen GL, Gelfand EW. Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2005; 288:L761-770.
Dakhama A, Park JW, Taube C, Chayama K, Balhorn A, Joetham A, Wei XD, Fan RH, Swasey C, Miyahara N, Kodama T, Alvarez A, Takeda K, Gelfand EW. The role of virus-specific immunoglobulin E in airway hyperresponsiveness. Am J Respir Crit Care Med. 2004; 170:952-9.
