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Providers > Researchers > Scott Alper
Diseases of the immune system such as sepsis, asthma, and atherosclerosis affect millions of people worldwide, and the incidence of many of these diseases is rising. My lab is focused on understanding the regulation of the innate immune response, particularly as it relates to the basis for such immunological diseases. We are using a comparative genomics approach in the nematode C. elegans and mammalian cell culture to identify novel regulators of the innate immune response.
Assistant Professor in the Integrated Department of Immunology
University Page for Dr. Alper
Victorino, F, and Alper, S. Identifying novel spatiotemporal regulators of innate immunity. Immunologic Research. 55: 3-9 (2013).
De Arras, L, Seng, A, Lackford, B, Keikhaee, MR, Bowerman, B, Freedman, JH, Schwartz, DA, Alper, S. An evolutionarily conserved innate immunity protein interaction network. J. Biol. Chem. 288: 1967-1978 (2013).
De Arras, L and Alper, S. Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing. PLOS Genetics 9(10):e1003855 (2013).
De Arras, L, Laws, R, Leach, S, Pontis, K, Freedman, JH, Schwartz, DA and Alper, S. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. Genetics published online Dec 20 (2013).
De Arras, L and Alper, S. Using RNAi-interference to investigate the innate immune response in mouse macrophages. J. Vis. Exp. in press (2013).
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