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Providers > Researchers > Paul R. Reynolds
National Jewish Health is strongly interested in Personalized Medicine as a means to improve all aspects of patient care. As Personalized Medicine requires a sophisticated and contemporary approach to molecular diagnostics, over the past several years I have developed a number of genetic tests relevant to the diseases frequently seen in the NJH clinic. These include but are not limited to Atopic Dermatitis and Immunodeficiency, the latter of which includes complement defects. I have also developed speciation and detection testing for a number of bacteria, particularly the genus Mycobacterium.
In close collaboration with the Advanced and Molecular Diagnostic Laboratories of National Jewish Health, I am spearheading our effort to use Next Generation Sequencing in CAP- and CLIA- approved clinical testing. At this stage we are testing NGS analysis of CFTR (mutated in Cystic Fibrosis) and the entire Complement Pathway (approximately 50 genes). In the near future we will be analyzing the Epidermal Differentiation Complex on Chromosome 1, for mutations that underlie Atopic Dermatitis and other diseases of the skin. We have also started to develop analysis of a panel of over 240 genes that are known to have mutations that may cause a Primary Immunodeficiency.
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